{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:33:34Z","timestamp":1790346814540,"version":"4.1.0"},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"unspecified","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec id=\"S2056472424008457_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008457_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008457_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008457_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. In the followed prospective cohort analysis, light-intensity physical activity was associated with a lower risk of hospitalisations due to self-harm behaviour in one genetic cluster (adjusted hazard ratio, 0.28 [95% CI, 0.08\u20130.96]), which was distinguished by three genetic variants: rs1432639, rs4543289 and rs11209948. Compliance with the guideline-level moderate-to-vigorous physical activities was not significantly related to the risk of self-harm behaviour.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008457_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>A genotype-specific dose of light-intensity physical activity reduces the risk of self-harm by around a fourth in depressive patients.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2024.845","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:17:53Z","timestamp":1738311473000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank"],"prefix":"10.1192","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-2965","authenticated-orcid":false,"given":"Jaegyun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doheon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"S2056472424008457_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13383"},{"key":"S2056472424008457_ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-019-0738-4"},{"key":"S2056472424008457_ref33","doi-asserted-by":"publisher","DOI":"10.5607\/en.2020.29.1.1"},{"key":"S2056472424008457_ref36","doi-asserted-by":"publisher","DOI":"10.1177\/20438087221092582"},{"key":"S2056472424008457_ref1","volume-title":"Depression and Other Common Mental Disorders: Global Health Estimates","year":"2017"},{"key":"S2056472424008457_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mhpa.2019.100303"},{"key":"S2056472424008457_ref24","unstructured":"24 IPAQ Research Committee. Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ)\u2013Short and Long Forms. IPAQ Research Committee, 2005 (https:\/\/sites.google.com\/view\/ipaq\/score)."},{"key":"S2056472424008457_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"S2056472424008457_ref13","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/bjsports-2022-106195","article-title":"Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews","volume":"57","author":"Ben","year":"2023","journal-title":"Br J Sports Med"},{"key":"S2056472424008457_ref23","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"S2056472424008457_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30034-1"},{"key":"S2056472424008457_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.040"},{"key":"S2056472424008457_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.08.070"},{"key":"S2056472424008457_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32010"},{"key":"S2056472424008457_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0090-3"},{"key":"S2056472424008457_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-023-02463-7"},{"key":"S2056472424008457_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1982-6"},{"key":"S2056472424008457_ref37","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20458"},{"key":"S2056472424008457_ref39","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e31825b34a0"},{"key":"S2056472424008457_ref40","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.12443"},{"key":"S2056472424008457_ref11","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Fiona","year":"2020","journal-title":"Br J Sports Med"},{"key":"S2056472424008457_ref19","first-page":"166298","article-title":"Genome-wide genetic data on ~500,000 UK biobank participants","author":"Clare","year":"[Preprint] 2017","journal-title":"bioRxiv"},{"key":"S2056472424008457_ref25","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/bjsports-2021-104050","article-title":"Reallocation of time between device-measured movement behaviours and risk of incident cardiovascular disease","volume":"56","author":"Rosemary","year":"2022","journal-title":"Br J Sports Med"},{"key":"S2056472424008457_ref38","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-7-35"},{"key":"S2056472424008457_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/ebmed-2016-110522"},{"key":"S2056472424008457_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mhpa.2019.100315"},{"key":"S2056472424008457_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3552"},{"key":"S2056472424008457_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112553"},{"key":"S2056472424008457_ref18","volume-title":"Field Descriptions and Derivation for Variables Related to Bipolar Disorder, major Depression status and Neuroticism Score","year":"2015"},{"key":"S2056472424008457_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32878"},{"key":"S2056472424008457_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291703007943"},{"key":"S2056472424008457_ref12","first-page":"6","article-title":"Genetic moderators of the impact of physical activity on depressive symptoms","volume":"5","author":"Dotson","year":"2016","journal-title":"J Frailty Aging"},{"key":"S2056472424008457_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075362"},{"key":"S2056472424008457_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"S2056472424008457_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30367-X"},{"key":"S2056472424008457_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3623"},{"key":"S2056472424008457_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.08.008"},{"key":"S2056472424008457_ref32","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32709"},{"key":"S2056472424008457_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4672"},{"key":"S2056472424008457_ref35","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.4175"}],"container-title":["BJPsych Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2056472424008457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:18:02Z","timestamp":1738311482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2056472424008457\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["S2056472424008457"],"URL":"https:\/\/doi.org\/10.1192\/bjo.2024.845","relation":{},"ISSN":["2056-4724"],"issn-type":[{"value":"2056-4724","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e27"}}