{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:24:40Z","timestamp":1754151880026,"version":"3.41.2"},"reference-count":46,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"unspecified","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec id=\"S2056472425100689_as1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>There are few economic evaluations of adjunctive psychosocial therapies for bipolar disorder.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472425100689_as2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>Estimate the cost\u2013utility of in-person psychosocial therapies for adults with bipolar disorder added to treatment as usual (TAU), from an Australian Government perspective.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472425100689_as3\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>We developed an economic model, estimating costs in 2021 Australian dollars (A$) and outcomes using quality-adjusted life-years (QALYs) gained and disability-adjusted life-years (DALYs) averted. The model compared psychoeducation, brief psychoeducation, carer psychoeducation, cognitive\u2013behavioural therapy (CBT) and family therapy when added to TAU (i.e. pharmacotherapy) over a year for adults (18\u201365 years) with bipolar disorder. The relative risk of relapse was sourced from two network meta-analyses and applied to the depressive phase in the base case. Probabilistic sensitivity analysis and one-way sensitivity analyses were conducted, assessing robustness of results.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472425100689_as4\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Carer psychoeducation was preferred in the base case when the willingness-to-pay (WTP) threshold is below A$1000 per QALY gained and A$1500 per DALY averted. Brief psychoeducation was preferred when WTP is between A$1000 and A$300 000 per QALY gained and A$1500 and A$450 000 per DALY averted. Family therapy was only preferred at WTP thresholds above A$300 000 per QALY gained or A$450 000 per DALY averted. In sensitivity analyses, brief psychoeducation was the preferred therapy. Psychoeducation and CBT were dominated (more costly and less effective) in base-case and sensitivity analyses.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472425100689_as5\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Carer and brief psychoeducation were found to be the most cost-effective psychosocial therapies, supporting use as adjunctive treatments for adults with bipolar disorder and their families in Australia.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2025.10068","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:25:45Z","timestamp":1753082745000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2013utility analysis of adjunctive psychosocial therapies in bipolar disorder"],"prefix":"10.1192","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-9448","authenticated-orcid":false,"given":"Mary Lou","family":"Chatterton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Yi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-6824","authenticated-orcid":false,"given":"Long Khanh-Dao","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-6946","authenticated-orcid":false,"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrine","family":"Mihalopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"S2056472425100689_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12005"},{"key":"S2056472425100689_ref28","unstructured":"28 Australian Bureau of Statistics. 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