{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:44:48Z","timestamp":1787021088948,"version":"build-2736575974"},"reference-count":42,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec id=\"S205647242510817X_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The decision-making process regarding antipsychotic continuation or discontinuation following remission from first-episode psychosis (FEP) remains complex and underresearched. While discontinuation increases the risk of relapse, concerns over long-term side-effects such as metabolic disturbances and extrapyramidal symptoms also exist. Current guidelines recommend maintaining antipsychotics for 1\u20135 years, emphasising shared decision-making (SDM) between clinicians and patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242510817X_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to explore the decision-making process and describe the factors influencing the decision to discontinue or continue antipsychotic treatment following remission from FEP, from the patients\u2019 perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242510817X_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A descriptive qualitative study was conducted with 12 individuals in remission from FEP who received care at early intervention services in Quebec, Canada. Data were collected through online semi-structured interviews and analysed thematically to identify key factors influencing treatment decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242510817X_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The decision-making process was activated by treatment reflection triggers and shaped by various perceptions (of illness, treatment and stigma) and relationships (with friends, family and the clinical team), ultimately leading to decisions to either discontinue, continue (at standard or reduced dose) or remain ambivalent. This dynamic process was guided by participants\u2019 motivators, such as well-being and societal contribution. Most participants felt that discontinuation discussions were not initiated by the clinical team.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242510817X_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The decision-making process is driven by motivators that were found to be linked to the concept of personal recovery. This study highlights the need for proactive, personalised discussions between clinicians and patients. Future research should focus on decision aids tailored to the FEP population to support SDM and improve treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjo.2025.10817","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:27:18Z","timestamp":1756970838000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Factors shaping the decision-making process to continue or discontinue antipsychotics: exploratory qualitative study of 12 individuals in remission from first-episode psychosis"],"prefix":"10.1192","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6697-1799","authenticated-orcid":false,"given":"Laurent","family":"B\u00e9chard","sequence":"first","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"Universit\u00e9 Laval"},{"name":"Quebec Mental Health University Institute, CIUSSS-CN"},{"name":"CAP \u2013 R\u00e9tablissement, CERVO Brain Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Anderson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"CAP \u2013 R\u00e9tablissement, CERVO Brain Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-853X","authenticated-orcid":false,"given":"Olivier","family":"Corbeil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"Quebec Mental Health University Institute, CIUSSS-CN"},{"name":"CAP \u2013 R\u00e9tablissement, CERVO Brain Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Huot-Lavoie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"CAP \u2013 R\u00e9tablissement, CERVO Brain Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-9043","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Brodeur","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"Quebec Mental Health University Institute, CIUSSS-CN"},{"name":"CAP \u2013 R\u00e9tablissement, CERVO Brain Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Abdel-Baki","sequence":"additional","affiliation":[{"name":"University of Montr\u00e9al"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mass\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Gabriel-Courval","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c8ve","family":"Cot\u00e9","sequence":"additional","affiliation":[{"name":"CAP \u2013 R\u00e9tablissement, CERVO Brain Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"},{"name":"VITAM - 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e193"}}