{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:05:53Z","timestamp":1785434753476,"version":"3.56.0"},"reference-count":45,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec id=\"S2056472425108600_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>According to existing evidence, during menopause transition, women with psychosis may present with exacerbated psychiatric symptoms, due to age-related hormonal changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472425108600_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to (a) replicate this evidence, using age as a proxy for peri\/menopausal status; (b) investigate how clinical presentation is affected by concomitant factors, including hyperprolactinaemia, dose and metabolism of prescribed antipsychotics using cross-sectional and longitudinal analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472425108600_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Secondary analysis on 174 women aged 18\u201365, from the IMPaCT (Improving physical health and reducing substance use in psychosis) randomised controlled trial. We compared women aged below (\n                      <jats:italic>N<\/jats:italic>\n                      = 65) and above 40 (\n                      <jats:italic>N<\/jats:italic>\n                      = 109) for (a) mental health status with the Positive and Negative Syndrome Scale (PANSS) and Montgomery Asberg Depression Rating Scale; (b) current medications and (c) prolactin levels, at baseline and at follow-up (12\/15 months later).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472425108600_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women aged above 40 showed higher baseline PANSS total score (mean \u00b1 s.d. = 53.4 \u00b1 14.1\n                      <jats:italic>v<\/jats:italic>\n                      . 48.0 \u00b1 13.0,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) and general symptoms scores (28.0 \u00b1 7.4\n                      <jats:italic>v<\/jats:italic>\n                      . 25.7 \u00b1 7.8,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) than their younger counterparts. Progressive sub-analysis revealed that this age-related difference was observed only in women with non-affective psychosis (\n                      <jats:italic>n<\/jats:italic>\n                      = 93) (PANSS total score: 57.1 \u00b1 13.6\n                      <jats:italic>v<\/jats:italic>\n                      . 47.0 \u00b1 14.4,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.005) and in those prescribed antipsychotic monotherapy with olanzapine or clozapine (\n                      <jats:italic>n<\/jats:italic>\n                      = 25) (PANSS total score: 63 \u00b1 16.4\n                      <jats:italic>v<\/jats:italic>\n                      . 42.8 \u00b1 10.9,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                    <jats:p>Among all women with hyperprolactinaemia, those aged above 40 also had higher PANSS positive scores than their younger counterparts. No longitudinal differences were found between age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472425108600_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women aged above 40 showed worse psychotic symptoms than younger women. This difference seems diagnosis-specific and may be influenced by antipsychotics metabolism. Further longitudinal data are needed considering the menopause transition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjo.2025.10860","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T05:31:22Z","timestamp":1764653482000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["The effect of age on the clinical presentation and treatment of women with psychosis: secondary analysis of the IMPaCT Randomised Clinical Trial"],"prefix":"10.1192","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-8391","authenticated-orcid":false,"given":"Maria Antonietta","family":"Nettis","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015803449","id-type":"ROR","asserted-by":"publisher"}],"name":"South London and Maudsley NHS Foundation Trust"},{"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of 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