{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:33:30Z","timestamp":1791484410329,"version":"4.3.4"},"reference-count":15,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"unspecified","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n\t  <jats:p>Medicinal cannabis has been trialled for Tourette syndrome in adults, but it has not been studied in adolescents. This open-label, single-arm trial study evaluated the feasibility, acceptability and signal of efficacy of medicinal cannabis in adolescents (12\u201318 years), using a \u03949-tetrahydrocannabinol:cannabidiol ratio of 10:15, with dose varying from 5 to 20 mg\/day based on body weight and response. The study demonstrated feasibility of recruitment, acceptability of study procedures, potential benefits and a favourable safety profile, with no serious adverse events. Commonly reported adverse events were tiredness and drowsiness, followed by dry mouth. Statistically significant improvement was observed in parent and clinician reports on tics (paired <jats:italic>t<\/jats:italic>-test <jats:italic>P<\/jats:italic> = 0.003), and behavioural and emotional issues (paired <jats:italic>t<\/jats:italic>-test <jats:italic>P<\/jats:italic> = 0.048) and quality of life as reported by the parent and young person (paired <jats:italic>t<\/jats:italic>-test <jats:italic>P<\/jats:italic> = 0.027 and 0.032, respectively). A larger-scale, randomised controlled trial is needed to validate these findings.<\/jats:p>","DOI":"10.1192\/bjo.2025.35","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:16:01Z","timestamp":1752138961000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Medicinal cannabis for tics in adolescents with Tourette syndrome"],"prefix":"10.1192","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-8306","authenticated-orcid":false,"given":"Valsamma","family":"Eapen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-I","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Cranswick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feroza","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidambaram","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Velalagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Efron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"S2056472425000353_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"S2056472425000353_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1234-988X(199612)6:4<203::AID-MPR165>3.3.CO;2-F"},{"key":"S2056472425000353_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01545.x"},{"key":"S2056472425000353_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00956.x"},{"key":"S2056472425000353_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200512000-00001"},{"key":"S2056472425000353_ref5","doi-asserted-by":"publisher","DOI":"10.1089\/can.2022.0091"},{"key":"S2056472425000353_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2019.12.003"},{"key":"S2056472425000353_ref13","volume-title":"ADHD Rating Scale 5 for Children and Adolescents: Checklists, Norms, and Clinical Interpretation","author":"DuPaul","year":"2016"},{"key":"S2056472425000353_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.607"},{"key":"S2056472425000353_ref15","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327890.02893.61"},{"key":"S2056472425000353_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.97"},{"key":"S2056472425000353_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2017.05.006"},{"key":"S2056472425000353_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-023-02169-w"},{"key":"S2056472425000353_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-014-0563-6"},{"key":"S2056472425000353_ref6","article-title":"Tetrahydrocannabinol and cannabidiol in Tourette syndrome","volume":"9","author":"Mosley","year":"2023","journal-title":"NEJM Evid"}],"container-title":["BJPsych Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2056472425000353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:16:01Z","timestamp":1752138961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2056472425000353\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["S2056472425000353"],"URL":"https:\/\/doi.org\/10.1192\/bjo.2025.35","relation":{},"ISSN":["2056-4724"],"issn-type":[{"value":"2056-4724","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e145"}}