{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:50:30Z","timestamp":1793245830932,"version":"4.5.0"},"reference-count":27,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"unspecified","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec id=\"S2056472426120420_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Two functional genetic polymorphisms,\n                      <jats:italic>ADH1B rs1229984<\/jats:italic>\n                      and\n                      <jats:italic>ALDH2 rs671<\/jats:italic>\n                      , play key roles in ethanol metabolism and are especially prevalent in East Asian populations. The\n                      <jats:italic>rs1229984<\/jats:italic>\n                      variant accelerates the conversion of ethanol to acetaldehyde, whereas\n                      <jats:italic>rs671<\/jats:italic>\n                      reduces enzymatic activity for converting acetaldehyde into acetic acid. These variants affect alcohol use disorder risk and have been implicated in various systemic conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120420_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To investigate the broader associations of\n                      <jats:italic>ADH1B rs1229984<\/jats:italic>\n                      and\n                      <jats:italic>ALDH2 rs671<\/jats:italic>\n                      with habitual alcohol use in large, unselected populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120420_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We analysed data from 146 374 Taiwanese adults (aged 20\u201390 years) enrolled in the Taiwan Biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120420_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both variants showed clear associations with habitual alcohol use. The\n                      <jats:italic>ADH1B rs1229984<\/jats:italic>\n                      CC genotype was associated with a higher prevalence of drinking, indicating a substantial contribution to alcohol-related behaviour. The\n                      <jats:italic>ALDH2 rs671<\/jats:italic>\n                      A allele was linked to markedly reduced drinking, reflecting known intolerance among carriers rather than implying a uniformly larger effect than\n                      <jats:italic>ADH1B<\/jats:italic>\n                      . Beyond alcohol use,\n                      <jats:italic>rs671<\/jats:italic>\n                      showed a protective association with gout, whereas\n                      <jats:italic>rs1229984<\/jats:italic>\n                      was not significantly associated with chronic diseases after correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120420_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this large population sample, both\n                      <jats:italic>ADH1B rs1229984<\/jats:italic>\n                      and\n                      <jats:italic>ALDH2 rs671<\/jats:italic>\n                      demonstrate meaningful, genotype-dependent effects on habitual alcohol use. Their combined effects underscore the importance of evaluating gene\u2013gene interactions rather than attributing disproportionate influence to a single locus.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjo.2026.12042","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:10:19Z","timestamp":1784628619000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Effect of\n                    <i>ALDH2 rs671<\/i>\n                    and\n                    <i>ADH1B rs1229984<\/i>\n                    polymorphisms on habitual alcohol use: evidence from a large Taiwanese cohort"],"prefix":"10.1192","volume":"12","author":[{"given":"Mu-En","family":"Liu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ymy8z76","id-type":"ROR","asserted-by":"publisher"}],"name":"Taipei Veterans General Hospital"},{"name":"National Yang Ming Chiao Tung 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-ShareAlike licence (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/), which permits re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e192"}}