{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:35:32Z","timestamp":1787924132466,"version":"build-2784847793"},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec id=\"S2056472426120651_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Social isolation and loneliness are recognised as important risk factors for various health outcomes. However, their impact on functional bowel disorders (FBDs) remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120651_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the associations of social isolation and loneliness with the risk of FBDs in a large prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120651_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We included 396 009 participants from UK Biobank who were free of cancer and FBDs at baseline. Social isolation and loneliness were assessed using validated self-reported questionnaires. Incident FBDs were ascertained during follow-up. Cox proportional hazards models were used to estimate hazard ratios and 95% CIs. Mediation, subgroup and sensitivity analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120651_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a mean follow-up of 15.2 years, 31 877 incident FBDs cases were recorded. Compared with the least isolated, the most isolated had a higher risk of FBDs (hazard ratio 1.15, 95% CI 1.11\u20131.20). Loneliness was also associated with higher risk (hazard ratio 1.28, 95% CI 1.21\u20131.35). The highest risk was observed among participants who were most isolated and lonely (hazard ratio 1.46, 95% CI 1.33\u20131.60). Depression, anxiety and low physical activity partially mediated the associations between social isolation\/loneliness and FBDs. The association between social isolation and FBDs risk appeared stronger among male, overweight and unemployed individuals, whereas middle-aged adults were more susceptible to loneliness-related risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120651_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Social isolation and loneliness were associated with a higher risk of FBDs, particularly when co-occurring. These findings underscore the potential relevance of social disconnection to FBDs and suggest that it may represent a target for future preventive strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjo.2026.12065","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:15:24Z","timestamp":1787922924000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Impact of social isolation and loneliness on the risk of functional bowel disorders: findings from a large-scale cohort study"],"prefix":"10.1192","volume":"12","author":[{"given":"Yan","family":"Ran","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03aq7kf18","id-type":"ROR","asserted-by":"publisher"}],"name":"Second Affiliated Hospital of Xi\u2019an Jiaotong 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