{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:20:46Z","timestamp":1786116046255,"version":"build-2736575974"},"reference-count":62,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec id=\"S2056472426120687_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with schizophrenia have shown distinct cancer incidence patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120687_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to assess whether their cancer-related mortality differs from the general population overall, by gender and by specific cancer types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120687_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We systematically searched Scopus, Web of Science, PsycINFO, PubMed and Embase, up to December 2025. Each record was independently screened by two reviewers, and data were independently extracted by two investigators. Two authors assessed the quality of the included articles with the Newcastle\u2013Ottawa Scale. Analyses were conducted using Stata version 16; between-study heterogeneity was evaluated with Cochran\u2019s\n                      <jats:italic>Q<\/jats:italic>\n                      -statistic and the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      -statistic, and potential sources of heterogeneity were further examined through exploratory meta-regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120687_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Meta-analysis of cohort studies showed that individuals with schizophrenia had a 55% higher risk of cancer-related death than the general population (standardised mortality ratio (SMR) 1.55; 95% CI 1.16\u20132.07). In gender-stratified analyses, SMRs for all cancers combined were 1.37 (95% CI 1.01\u20131.87) in men and 1.43 (95% CI 1.15\u20131.79) in women. Site-specific SMRs were 1.77 (95% CI 1.17\u20132.68) for breast, 2.40 (95% CI 2.35\u20132.45) for respiratory, 1.54 (95% CI 1.35\u20131.76) for gastrointestinal, 2.32 (95% CI 0.72\u20137.45) for haematologic, 4.43 (95% CI 0.71\u201327.62) for skin and soft tissue, 3.03 (95% CI 1.96\u20134.69) for urogenital and 1.01 (95% CI: 0.36\u20132.83) for other cancers, although precision varied considerably across cancer sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056472426120687_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Schizophrenia was associated with substantially elevated cancer-related mortality compared with the general population. These findings underscore the need for earlier cancer detection and guideline-concordant, integrated physical and mental healthcare for this high-risk group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjo.2026.12068","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:14:36Z","timestamp":1786000476000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Cancer-related mortality among individuals with\u00a0schizophrenia: systematic review and meta-analysis of cohort studies"],"prefix":"10.1192","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-667X","authenticated-orcid":false,"given":"Seyyed Muhammad Mahdi","family":"Mahdavinoor","sequence":"first","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aghil","family":"Mollaei","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Golzar","sequence":"additional","affiliation":[{"name":"Islamic Azad University of Qom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Kargar-Soleimanabad","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-6942","authenticated-orcid":false,"given":"Amir-Hassan","family":"Bordbari","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melika","family":"Amiri","sequence":"additional","affiliation":[{"name":"Islamic Azad University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hosein","family":"Rafiee","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Seddigh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c4pz451","id-type":"ROR","asserted-by":"publisher"}],"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"S2056472426120687_ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-019-0165-6"},{"key":"S2056472426120687_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002808"},{"key":"S2056472426120687_ref32","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.278"},{"key":"S2056472426120687_ref62","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby058"},{"key":"S2056472426120687_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-523"},{"key":"S2056472426120687_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.01.006"},{"key":"S2056472426120687_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30078-0"},{"key":"S2056472426120687_ref49","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2000.101005382.x"},{"key":"S2056472426120687_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.05.007"},{"key":"S2056472426120687_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24383"},{"key":"S2056472426120687_ref24","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.195776"},{"key":"S2056472426120687_ref30","first-page":"1","article-title":"Statistical methods in cancer research. 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Wells, G , Shea, B , O\u2019Connell, D , Peterson, J , Welch, V , Losos, M , et\u00a0al.\u00a0The Newcastle\u2013Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-analyses. 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