{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:11:09Z","timestamp":1780643469415,"version":"3.54.1"},"reference-count":26,"publisher":"Royal College of Psychiatrists","issue":"422","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"unspecified","delay-in-days":23049,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. ment. sci"],"published-print":{"date-parts":[[1955,1]]},"abstract":"<jats:p>Theoretical models ranging from neurological to analytical have been introduced in the hope of providing new insights into psychopathology. The flesh and blood model is of more recent origin in this field. The experimental or model psychosis results from giving \u201cnormals\u201d drugs which bring about a psychotic-like experience for a few hours. As is the case with theoretical models, the flesh and blood models are not accurate representations of the naturally occurring psychosis. In fact, the variability manifest in most naturally occurring psychoses makes the existence of an accurate model impossible. A model, whether carefully planned and developed or accidentally discovered, is useful to the extent that it assists us in better understanding the naturally occurring process it approximates. It is useful if it enables us to set up and test hypotheses which contribute additional knowledge about disease aetiology, mechanisms, or treatment. The model psychosis to be studied in this paper is that produced by lysergic acid diethylamide (LSD).<\/jats:p>","DOI":"10.1192\/bjp.101.422.12","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T14:02:31Z","timestamp":1218031351000},"page":"12-27","source":"Crossref","is-referenced-by-count":20,"title":["Nicotinic Acid Modified Lysergic Acid Diethylamide Psychosis"],"prefix":"10.1192","volume":"101","author":[{"given":"N.","family":"Agnew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hoffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"S0368315X00038123_ref25","doi-asserted-by":"crossref","unstructured":"Fischer R. , and Agnew N. , \u201cCompetitive inhibition of drug-produced experimental psychoses\u201d. Paper to be presented at the fall meeting of the Am. Chem. Soc. (Div. Biol. Chem.), N.Y., September, 1954.","DOI":"10.1007\/BF00625685"},{"key":"S0368315X00038123_ref11","first-page":"261","article-title":"\u201cNicotinic acid in the treatment of certain depressed states: a preliminary report\u201d","volume":"52","author":"Washburne","year":"1950","journal-title":"Annals of Internal Medicine"},{"key":"S0368315X00038123_ref26","unstructured":"Elkes J. , Private communication."},{"key":"S0368315X00038123_ref7","first-page":"1297","article-title":"\u201cThe effect of succinate in mescaline hallucination\u201d","volume":"33","author":"Schueler","year":"1948","journal-title":"J. Lab. and Clin. Med."},{"key":"S0368315X00038123_ref23","unstructured":"Stefaniuk W. 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Nervenartz"},{"key":"S0368315X00038123_ref13","first-page":"21","article-title":"\u201cTreatment of delirium, psychoses and coma due to drugs\u201d","volume":"570","author":"Gould","year":"1953","journal-title":"Lancet"},{"key":"S0368315X00038123_ref5","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.99.417.804"},{"key":"S0368315X00038123_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.16.1.7"},{"key":"S0368315X00038123_ref4","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.108.12.896"},{"key":"S0368315X00038123_ref3","first-page":"241","article-title":"\u201cLSD 25 as an aid in psychotherapy (preliminary report of a new drug)\u201d","volume":"11","author":"Busch","year":"1950","journal-title":"Dis. Nerv. System"},{"key":"S0368315X00038123_ref15","first-page":"817","article-title":"\u201cPsychophysische korrelationene-VIII: Modellversuche zum Schizophrenieproblem, Lysergsaeure-diaethylamide und Mescalin\u201d","volume":"81","author":"Fischer","year":"1951","journal-title":"Schweiz. Med. Wschr."},{"key":"S0368315X00038123_ref19","first-page":"9","article-title":"\u201cKlinische Erfahrungen an Geisteskranken mit lysergs\u00e4ure di\u00e4thylamid (Clinical experiences in mental patients with lysergic acid-diethylamide)\u201d","volume":"24","author":"Condrau","year":"1949","journal-title":"Ejnar Munksgaard, Copenhagen"},{"key":"S0368315X00038123_ref20","first-page":"402","article-title":"\u201cZur Psychopathologie der Lysergs\u00e4ure-di\u00e4thylamid-wirkung (On the psychopathology of the effect of lysergic acid diethylamide)\u201d","volume":"2","author":"Becker","year":"1949","journal-title":"Wien Ztschr. Nervenh."}],"container-title":["Journal of Mental Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0368315X00038123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T01:44:01Z","timestamp":1559871841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0368315X00038123\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1955,1]]},"references-count":26,"journal-issue":{"issue":"422","published-print":{"date-parts":[[1955,1]]}},"alternative-id":["S0368315X00038123"],"URL":"https:\/\/doi.org\/10.1192\/bjp.101.422.12","relation":{},"ISSN":["0368-315X","2514-9946"],"issn-type":[{"value":"0368-315X","type":"print"},{"value":"2514-9946","type":"electronic"}],"subject":[],"published":{"date-parts":[[1955,1]]}}}