{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T11:02:39Z","timestamp":1649070159652},"reference-count":3,"publisher":"Royal College of Psychiatrists","issue":"437","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"unspecified","delay-in-days":21680,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. ment. sci"],"published-print":{"date-parts":[[1958,10]]},"abstract":"<jats:p>Cyclizine hydrochloride (1-benzhydryl-4-methylpiperazine monohydrochloride) is a popular remedy for motion-sickness. The success which is reputed to attend the use of the drug in this condition may be a function of of two distinct effects: (<jats:italic>a<\/jats:italic>) a direct, specific inhibition of the vestibular mechanism; (<jats:italic>b<\/jats:italic>) a general, central inhibition or sedation. A consideration of the latter, rather than the former, suggested the possibility that cyclizine might prove to be of value as a potential \u201ctranquillizer\u201d. A controlled clinical trial was carried out in order to establish whether any tranquillizing effects might be associated with the use of the drug in a number of chronic psychotics, all of whom manifested some gross disturbance of behaviour. This paper describes the experimental method which was used; the results which were obtained; and a general comment upon the possible implications of the results in relation to other drugs used in psychiatry.<\/jats:p>","DOI":"10.1192\/bjp.104.437.1219","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T18:02:31Z","timestamp":1218045751000},"page":"1219-1225","source":"Crossref","is-referenced-by-count":0,"title":["A Controlled Investigation of the Effects of Cyclizine Hydrochloride in Chronic Psychosis"],"prefix":"10.1192","volume":"104","author":[{"given":"B. G.","family":"Fleming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D. C.","family":"Currie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"S0368315X00039724_ref3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.102.429.790"},{"key":"S0368315X00039724_ref2","first-page":"63","author":"Raymond","year":"1957","journal-title":"ibid."},{"key":"S0368315X00039724_ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5014.306"}],"container-title":["Journal of Mental Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0368315X00039724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T20:34:23Z","timestamp":1559766863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0368315X00039724\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1958,10]]},"references-count":3,"journal-issue":{"issue":"437","published-print":{"date-parts":[[1958,10]]}},"alternative-id":["S0368315X00039724"],"URL":"https:\/\/doi.org\/10.1192\/bjp.104.437.1219","relation":{},"ISSN":["0368-315X","2514-9946"],"issn-type":[{"value":"0368-315X","type":"print"},{"value":"2514-9946","type":"electronic"}],"subject":[],"published":{"date-parts":[[1958,10]]}}}