{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:30:08Z","timestamp":1780579808304,"version":"3.54.1"},"reference-count":6,"publisher":"Royal College of Psychiatrists","issue":"456","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"unspecified","delay-in-days":20249,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. ment. sci"],"published-print":{"date-parts":[[1962,9]]},"abstract":"<jats:p>The mono-amine oxidase inhibitors, of which phenelzine (\u201cNardil\u201d) is one example, were introduced for the treatment of depressive illness as a result of the observation that iproniazid, which is a mono-amine oxidase inhibitor, produced euphoria and increased mental alertness in some tuberculous patients to whom it was given. Trials of iproniazid in mental illness were carried out (Loomer<jats:italic>et al.<\/jats:italic>, 1957; Cesarman, 1959), but it was found to be very liable to give rise to side-effects, being particularly toxic to the liver. Other less toxic mono-amine oxidase inhibitors such as phenelzine, which is chemically related to iproniazid, were later developed.<\/jats:p>","DOI":"10.1192\/bjp.108.456.708","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T18:04:14Z","timestamp":1218045854000},"page":"708-710","source":"Crossref","is-referenced-by-count":13,"title":["A clinical comparison of phenelzine and electro-convulsive therapy in the treatment of depressive illness"],"prefix":"10.1192","volume":"108","author":[{"given":"W. J.","family":"Stanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"S0368315X00235536_ref2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1749-6632.1959.tb49274.x","volume":"80","author":"Cesarman","year":"1959","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"S0368315X00235536_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(195801)14:1<77::AID-JCLP2270140124>3.0.CO;2-Q"},{"key":"S0368315X00235536_ref3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.105.438.182"},{"key":"S0368315X00235536_ref4","first-page":"129","volume":"8","author":"Loomer","year":"1957","journal-title":"Psych. Res. Rep. Amer. Psychiat. Ass."},{"key":"S0368315X00235536_ref1","first-page":"1238","volume":"ii","year":"1959","journal-title":"B.M.J."},{"key":"S0368315X00235536_ref6","volume-title":"Non-parametric Statistics for the Behavioural Sciences","author":"Siegel","year":"1956"}],"container-title":["Journal of Mental Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0368315X00235536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T02:39:31Z","timestamp":1709174371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0368315X00235536\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,9]]},"references-count":6,"journal-issue":{"issue":"456","published-print":{"date-parts":[[1962,9]]}},"alternative-id":["S0368315X00235536"],"URL":"https:\/\/doi.org\/10.1192\/bjp.108.456.708","relation":{},"ISSN":["0368-315X","2514-9946"],"issn-type":[{"value":"0368-315X","type":"print"},{"value":"2514-9946","type":"electronic"}],"subject":[],"published":{"date-parts":[[1962,9]]}}}