{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:17:57Z","timestamp":1772691477537,"version":"3.50.1"},"reference-count":28,"publisher":"Royal College of Psychiatrists","issue":"518","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":17925,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1969,1]]},"abstract":"<jats:p>Neurosyphilis, causing a psychotic illness of such severity as to necessitate admission to a mental hospital, though now rare, has not been completely eradicated. This study is based on 91 psychotic patients with neurosyphilis admitted to six mental hospitals between 1950 and 1965. Its main purpose is to ascertain the incidence, and to present the natural history of the neurosyphilitic psychoses during a period when antibiotics were available. It is likely that some patients in this series were given penicillin for an intercurrent infection in complete ignorance of the underlying syphilitic process. Indeed, Joffe, Black and Floyd (1968) and Heathfield (1968) have reported modifications in the clinical picture of neurosyphilis, tending to mask the diagnosis, caused by earlier administration of antibiotics for intercurrent infections. Thus the widespread use of antibiotics, though greatly reducing the incidence of neurosyphilitic psychosis, may well have increased the mutability of the disease as reflected in its changing prevalence, distribution and clinical characteristics.<\/jats:p>","DOI":"10.1192\/bjp.115.518.31","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T14:04:14Z","timestamp":1218031454000},"page":"31-38","source":"Crossref","is-referenced-by-count":60,"title":["The Neurosyphilitic Psychoses Today"],"prefix":"10.1192","volume":"115","author":[{"given":"Kenneth","family":"Dewhurst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000029883_ref13","first-page":"211","article-title":"\u201cChanging clinical picture of neurosyphilis. Report of seven unusual cases.\u201d","volume":"i","author":"Joffe","year":"1968","journal-title":"Ibid."},{"key":"S0007125000029883_ref26","first-page":"141","article-title":"\u201cThe incidence and clinical features of general paresis.\u201d","volume":"3","author":"Varma","year":"1952","journal-title":"Indian J. Neurol. Psychiat."},{"key":"S0007125000029883_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/25.1.19"},{"key":"S0007125000029883_ref28","unstructured":"Wilson , Kinnier S. A. (1940). Neurology. London."},{"key":"S0007125000029883_ref15","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1192\/bjp.107.450.819","article-title":"\u201cSchizophrenia\u2014a hundred years ago and today.\u201d","volume":"107","author":"Klaf","year":"1961","journal-title":"J. ment. Sci."},{"key":"S0007125000029883_ref19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1192\/bjp.108.457.747","article-title":"\u201cA social and clinical study of delusions in schizophrenia.\u201d","volume":"108","author":"Lucas","year":"1962","journal-title":"J. ment. Sci."},{"key":"S0007125000029883_ref18","unstructured":"Lomholt T. M. (1944). \u201cClinic and progress of malaria-treated paralysis.\u201d Acta psychiat. neurol. Scand., Suppl. 30."},{"key":"S0007125000029883_ref10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1192\/bjp.105.440.594","article-title":"\u201cThe origin and spread of dementia paralytica.\u201d","volume":"105","author":"Hare","year":"1959","journal-title":"J. ment. Sci."},{"key":"S0007125000029883_ref12","first-page":"1751","article-title":"\u201cThe return of the venereal diseases.\u201d","volume":"i","author":"Jefferiess","year":"1962","journal-title":"Ibid."},{"key":"S0007125000029883_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5594.765-a"},{"key":"S0007125000029883_ref17","first-page":"1082","article-title":"\u201cGeneral paresis of the insane in Peking between 1933\u20131943.\u201d","volume":"106","author":"Liu","year":"1960","journal-title":"J. meat. Sci."},{"key":"S0007125000029883_ref4","first-page":"1003","volume":"2","author":"Bruetsch","year":"1959","journal-title":"American Handbook of Psychiatry"},{"key":"S0007125000029883_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/BF00356098"},{"key":"S0007125000029883_ref21","first-page":"252","volume-title":"Report for the Year 1958","volume":"59","year":"1959"},{"key":"S0007125000029883_ref5","volume-title":"Psychological Medicine","author":"Craig","year":"1905"},{"key":"S0007125000029883_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5277.524"},{"key":"S0007125000029883_ref7","unstructured":"Golding D. R. (1967). Personal communication."},{"key":"S0007125000029883_ref23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1192\/bjp.76.314.524","article-title":"\u201cThe aetiology of general paralysis of the insane.\u201d","volume":"76","author":"Power","year":"1930","journal-title":"J. ment. Sci."},{"key":"S0007125000029883_ref1","first-page":"165","volume":"8","author":"Bostroem","year":"1930","journal-title":"Handbuch der Geisteskrankheiten"},{"key":"S0007125000029883_ref20","unstructured":"McInnes R. G. (1965). Personal communication."},{"key":"S0007125000029883_ref2","volume-title":"Diseases of the Nervous System","author":"Brain","year":"1962"},{"key":"S0007125000029883_ref8","unstructured":"Golding D. R. (1968). Personal communication."},{"key":"S0007125000029883_ref9","first-page":"557","article-title":"\u201cPenicillin treatment of general paresis (dementia paralytica).\u201d","volume":"81","author":"Hahn","year":"1959","journal-title":"A.M.A. Arch. Neurol, and Psychiat."},{"key":"S0007125000029883_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)90049-0"},{"key":"S0007125000029883_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1956.tb04719.x"},{"key":"S0007125000029883_ref25","unstructured":"Stoddart W. H. B. (1912). Mind and its Disorders. Second edition. London."},{"key":"S0007125000029883_ref14","first-page":"355","article-title":"\u201cDrugs in the treatment of syphilis.\u201d","volume":"i","author":"King","year":"1959","journal-title":"Ibid."},{"key":"S0007125000029883_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1957.tb07548.x"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000029883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T16:40:40Z","timestamp":1559407240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000029883\/type\/journal_article"}},"subtitle":["A Survey of 91 Cases"],"short-title":[],"issued":{"date-parts":[[1969,1]]},"references-count":28,"journal-issue":{"issue":"518","published-print":{"date-parts":[[1969,1]]}},"alternative-id":["S0007125000029883"],"URL":"https:\/\/doi.org\/10.1192\/bjp.115.518.31","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,1]]}}}