{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T07:41:20Z","timestamp":1709192480334},"reference-count":14,"publisher":"Royal College of Psychiatrists","issue":"580","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":16040,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1974,3]]},"abstract":"<jats:p>The presumed carcinogenic and chromosome-breaking potential of d-lysergic acid diethylamide (d-LSD 25) in human somatic cells has been reviewed by Fernandez<jats:italic>et al.<\/jats:italic>(1973). Reports concerning its teratogenic effect in experimental animals and man have been either contradictory or inconclusive. The following possible teratogenic mechanisms may be considered: (1) A direct effect on organogenesis of LSD ingested by the mother during early pregnancy; (2) A similar disturbance of organogenesis by a persistent metabolite of LSD ingested by the mother at some time prior to the pregnancy; (3) Chromosome damage or point mutations in parental germ cells exposed to LSD before initiation of a pregnancy.<\/jats:p>","DOI":"10.1192\/bjp.124.3.296","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"296-298","source":"Crossref","is-referenced-by-count":5,"title":["Cytogenetic Studies in the Offspring of Lsd Users"],"prefix":"10.1192","volume":"124","author":[{"given":"J.","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Masterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Power","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000243420_ref14","article-title":"\u2018Lysergic acid diethylamide and mutation.\u2019","volume":"62","author":"Zetterberg","year":"1969","journal-title":"Hereditas"},{"key":"S0007125000243420_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/2221170b0"},{"key":"S0007125000243420_ref12","doi-asserted-by":"publisher","DOI":"10.1038\/223095a0"},{"key":"S0007125000243420_ref11","first-page":"47","article-title":"\u2018Mutagenic effects of LSD-25 in drosophila melanogaster.\u2019","volume":"30","author":"Tobin","year":"1969","journal-title":"Diseases of the Nervous System"},{"key":"S0007125000243420_ref8","first-page":"78","volume-title":"Second Report of the Committee on the Hazards to Man of Nuclear and Allied Radiations","year":"1968"},{"key":"S0007125000243420_ref3","doi-asserted-by":"crossref","DOI":"10.1126\/science.172.3982.431","article-title":"\u2018LSD and genetic damage: is LSD chromosome damaging, carcinogenic, mutagenic or teratogenic.\u2019","volume":"172","author":"Dishotsky","year":"1971","journal-title":"Science"},{"key":"S0007125000243420_ref2","first-page":"2","volume-title":"Eugenics Laboratory Memoirs","volume":"vol. 42","author":"Court Brown","year":"1966"},{"key":"S0007125000243420_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420060110"},{"key":"S0007125000243420_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/2231061a0"},{"key":"S0007125000243420_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)91569-9"},{"key":"S0007125000243420_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1973.tb01816.x"},{"key":"S0007125000243420_ref10","article-title":"\u2018Quantity of radiation received by reproduction organs of patients during routine diagnostic X-ray examinations.\u2019","volume":"27","author":"Stanford","year":"1955","journal-title":"British Journal of Radiology"},{"key":"S0007125000243420_ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3845.1022"},{"key":"S0007125000243420_ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3842.694"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000243420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T06:59:13Z","timestamp":1709189953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000243420\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,3]]},"references-count":14,"journal-issue":{"issue":"580","published-print":{"date-parts":[[1974,3]]}},"alternative-id":["S0007125000243420"],"URL":"https:\/\/doi.org\/10.1192\/bjp.124.3.296","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,3]]}}}