{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:35:10Z","timestamp":1756996510464},"reference-count":18,"publisher":"Royal College of Psychiatrists","issue":"588","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":15795,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>A previous paper (Malcolm and Madden, 1973) has described the use of disulfiram implantation as a method of treatment for some alcoholics. The results obtained were satisfactory, measured in terms of duration of abstinence and social improvements made in the post-implant period. However, it was suggested that the success of the implant might be due to psychological rather than pharmacological factors. In an effort to clarify the nature of any deterrent effect of the implant, further clinical and biochemical evidence has been collected.<\/jats:p>","DOI":"10.1192\/bjp.125.5.485","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T18:35:43Z","timestamp":1218566143000},"page":"485-489","source":"Crossref","is-referenced-by-count":42,"title":["Disulfiram Implantation Critically Evaluated"],"prefix":"10.1192","volume":"125","author":[{"given":"M. T.","family":"Malcolm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Madden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000058219_ref17","unstructured":"Williams A. E. (1974) The analysis of carbon disulphide in exhaled air by cathode ray polarography. Medical Laboratory Technology, In press."},{"key":"S0007125000058219_ref13","first-page":"6","article-title":"Results of treatment with Esperal implantation","volume":"15","author":"Mieniewski","year":"1967","journal-title":"Probl. Alkzmu. Wars."},{"key":"S0007125000058219_ref2","article-title":"A simple method for the determination of Antabus and blood levels obtained experimentally in animals and clinically in man","volume":"39","author":"Divatia","year":"1952","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0007125000058219_ref5","article-title":"The sensitising effect of tetraethylthiuramdisulphide to ethyl-alcohol","volume":"4","author":"Hald","year":"1948","journal-title":"Acta Pharmacologica et Toxicobgia"},{"key":"S0007125000058219_ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00365515009049871"},{"key":"S0007125000058219_ref7","first-page":"7","article-title":"Evaluation of personal experiences in treatment of alcoholics by Esperai implantation","volume":"14","author":"Hrynkiewicz","year":"1966","journal-title":"Probl. Alkzmu. Wars."},{"key":"S0007125000058219_ref9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.123.1.41"},{"key":"S0007125000058219_ref16","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.124.1.42"},{"key":"S0007125000058219_ref1","doi-asserted-by":"crossref","unstructured":"Brown M. , Porter G. S. & Williams A. E. (1974) The determination of disulfiram in blood and of exhaled carbon disulphide using cathode ray polarography. Journal of Pharmacy and Pharmacology. In press.","DOI":"10.1111\/j.2042-7158.1974.tb10123.x"},{"key":"S0007125000058219_ref6","article-title":"A drug sensitising the organism to ethyl alcohol","volume":"ii","author":"Hald","year":"1948","journal-title":"Lancet"},{"key":"S0007125000058219_ref8","first-page":"228","article-title":"Disulfiram implantation","volume":"4","author":"Kellam","year":"1969","journal-title":"Journal of Alcoholism"},{"key":"S0007125000058219_ref10","unstructured":"Marie C. (1955) Th\u00e8se de Paris. (Cit Jacques, D. (1970). Study of the use of disulfiram implants in the treatment of alcoholism. Centre International Alcoologie\/Toxicomanies, Monograph Number 2, Lausanne.)"},{"key":"S0007125000058219_ref12","article-title":"Carbon disulphide in the expired air of disulfiram treated subjects","volume":"132","author":"Merlevede","year":"1961","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"S0007125000058219_ref14","first-page":"144p","article-title":"The determination of low concentrations of disulfiram by cathode ray polarography","volume":"24","author":"Porter","year":"1972","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"S0007125000058219_ref15","first-page":"8","article-title":"Esperal treatment of alcoholism in the general hospital","volume":"18","author":"Waclawik","year":"1970","journal-title":"Probl. Alkzmu. Wars."},{"key":"S0007125000058219_ref18","article-title":"Effect of alcohol on workers with carbon disulphide","volume":"109","author":"Williams","year":"1937","journal-title":"Journal of the American Medical Association"},{"key":"S0007125000058219_ref11","article-title":"Treatment of alcoholism with a sensitising drug","volume":"ii","author":"Martensen-Larsen","year":"1948","journal-title":"Lancet"},{"key":"S0007125000058219_ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00365515009049870"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000058219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T16:50:48Z","timestamp":1559148648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000058219\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":18,"journal-issue":{"issue":"588","published-print":{"date-parts":[[1974,11]]}},"alternative-id":["S0007125000058219"],"URL":"https:\/\/doi.org\/10.1192\/bjp.125.5.485","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}