{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:16:49Z","timestamp":1757542609675},"reference-count":15,"publisher":"Royal College of Psychiatrists","issue":"588","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":15795,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>In 1959, J. M. Roberts claimed that in 50 depressed women aged 40\u201360 years the response to the intravenous injection of 15 mg. methylamphetamine differentiated significantly between those diagnosed as \u2018psychotic\u2019 and those diagnosed as \u2018neurotic\u2019. Following the injection each patient was observed closely for two to three hours, and in the great majority one of two responses occurred. Either the patient experienced a \u2018sustained period of general uplift of mood and a feeling of greater well-being'\u2014the \u2018normalization\u2019 response; or the patient showed \u2018an immediate, or almost immediate, intensification of symptoms, particularly a worsening of any agitation present, often together with a deepening of the depressive affect'\u2014the \u2018intensification\u2019 response. In only two patients, both with neurotic depression, was it not possible to classify the response.<\/jats:p>","DOI":"10.1192\/bjp.125.5.496","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"496-499","source":"Crossref","is-referenced-by-count":34,"title":["Response of Depressed Patients to Methylamphetamine"],"prefix":"10.1192","volume":"125","author":[{"given":"L. 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The application of specific tests","volume":"105","author":"Roberts","year":"1959","journal-title":"Journal of Mental Science"},{"key":"S0007125000058232_ref5","doi-asserted-by":"publisher","DOI":"10.3109\/00048677209159687"},{"key":"S0007125000058232_ref7","article-title":"Circadian rhythms","volume":"2","author":"Leader","year":"1970","journal-title":"The Medical Journal of Australia"},{"key":"S0007125000058232_ref8","article-title":"Notes from the logbook of a psychopharmacological research unit, II","volume":"9","author":"Lehmann","year":"1964","journal-title":"Canadian Psychiatric Association Journal"},{"key":"S0007125000058232_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.16.1.7"},{"key":"S0007125000058232_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-195402000-00001"},{"key":"S0007125000058232_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000058232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T20:50:08Z","timestamp":1559163008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000058232\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":15,"journal-issue":{"issue":"588","published-print":{"date-parts":[[1974,11]]}},"alternative-id":["S0007125000058232"],"URL":"https:\/\/doi.org\/10.1192\/bjp.125.5.496","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}