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Cyclic AMP is functionally closely related, and possibly fundamental, to the action of catecholamines and serotonin, both of which have been implicated in the amine hypothesis of depression (Granville-Grossman, 1971). Cyclic AMP is formed from ATP by the action of an enzyme adenyl cyclase, and it is degraded by the enzyme cyclic-AMP-phosphodiesterase<jats:italic>(Lancet<\/jats:italic>, Editorial, 1970) both of which occur in brain.<\/jats:p>","DOI":"10.1192\/bjp.126.1.49","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"49-55","source":"Crossref","is-referenced-by-count":22,"title":["Urinary Cyclic AMP in \u2018Endogenous' and \u2018Neurotic\u2019 Depression"],"prefix":"10.1192","volume":"126","author":[{"given":"K.","family":"Sinanan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. 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