{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:05:24Z","timestamp":1762160724055},"reference-count":64,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":15309,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1976,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fifty-five patients with presenile dementia were examined. There were 28 women and 27 men, and the mean age was 59 and 56 years respectively at the time of the study. A large series of psychometric tests was used, and with the aid of age-matched non-demented controls five significantly different cognitive reduction groups could be identified. In the demented patients the regional cerebral blood flow (rCBF) was determined with an eight-detector or 32-detector equipment. There was a rough proportionality between the cognitive reduction and a decrease of the cerebral blood flow (especially the flow in the grey matter). In addition, certain regional flow abnormalities correlated with specific cognitive functions in a manner resembling the cognitive defects found in focal brain lesions in the same region. Thus, patients who showed only memory disturbances demonstrated a focal flow reduction in the temporal region. More severely affected patients, with reduction of verbal abilities and signs of agnosia, showed very low flows in occipitotemporo-parietal parts of the hemisphere. The results offer a principal confirmation of the dynamic field theory concerning the functional organization of the cerebral cortex (Luria, 1966).<\/jats:p>","DOI":"10.1192\/bjp.128.3.209","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"209-222","source":"Crossref","is-referenced-by-count":94,"title":["Cognitive Reduction in Presenile Dementia Related to Regional Abnormalities of the Cerebral Blood Flow"],"prefix":"10.1192","volume":"128","author":[{"given":"Bo","family":"Hagberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Ingvar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000092369_ref64","doi-asserted-by":"publisher","DOI":"10.1037\/h0057639"},{"key":"S0007125000092369_ref63","doi-asserted-by":"publisher","DOI":"10.1002\/9780470719749"},{"key":"S0007125000092369_ref14","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1960.11.2.147"},{"key":"S0007125000092369_ref62","volume-title":"Brain Damage and the Mind.","author":"Williams","year":"1970"},{"key":"S0007125000092369_ref18","article-title":"Kognitiva defekter och rCBF vid tidiga demenstillst\u00e5nd","volume":"71","author":"Hagberg","year":"1974","journal-title":"L\u00e4kartidningen"},{"key":"S0007125000092369_ref59","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1965.tb00473.x"},{"key":"S0007125000092369_ref52","unstructured":"Roth M. & Myers D. H. (1969) The diagnosis of dementia. British Journal of Hospital Medicine, March 1969, pp. 705\u201317."},{"key":"S0007125000092369_ref58","doi-asserted-by":"crossref","unstructured":"Wechsler D. (1958) The Measurements and Appraisal of Adult Intelligence. Fourth ed. Baltimore.","DOI":"10.1037\/11167-000"},{"key":"S0007125000092369_ref47","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1964.tb00425.x"},{"key":"S0007125000092369_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1964.tb05736.x"},{"key":"S0007125000092369_ref13","article-title":"Cerebral blood flow and metabolism in psychosis of senility","volume":"113","author":"Freyhan","year":"1951","journal-title":"Journal of Nervous and Mental Diseases"},{"key":"S0007125000092369_ref44","volume-title":"Clinical Psychiatry.","author":"Mayer-Gross","year":"1969"},{"key":"S0007125000092369_ref5","unstructured":"Brun A. , Gustafson L. & Ingvar D. H. (1975) Neuropathological findings related to neuropsychiatric symptoms and regional cerebral blood flow in presenile dementia. VIIth International Congress of Neuropathology, Budapest."},{"key":"S0007125000092369_ref60","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.5.367"},{"key":"S0007125000092369_ref27","article-title":"Influence of mental activity upon regional cerebral blood flow in man","volume":"41","author":"H\u2298edt-Rasmussen","year":"1965","journal-title":"Acta Neurologica Scandinavica"},{"key":"S0007125000092369_ref61","volume-title":"Intellectual Impairment in Diffuse Cerebral Lesions.","author":"Willanger","year":"1970"},{"key":"S0007125000092369_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1974.tb09713.x"},{"key":"S0007125000092369_ref49","unstructured":"Prien T. (1957) Manual till USTM-provet. Skandinaviska Testf\u00f6rlaget."},{"key":"S0007125000092369_ref48","volume-title":"Clinical Aspects of Dementia.","author":"Pearce","year":"1973"},{"key":"S0007125000092369_ref45","article-title":"Psychological defects produced by temporal lobe excision","volume":"36","author":"Milner","year":"1958","journal-title":"Publ. Association for Research in Nervous and Mental Diseases"},{"key":"S0007125000092369_ref19","unstructured":"Hagberg B. A correlation of psychometry and rCBF in patients with presenile dementia. To be published."},{"key":"S0007125000092369_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1957.tb09467.x"},{"key":"S0007125000092369_ref37","article-title":"The relationship between clinical evaluation of mental deterioration, psychological test results and the cerebral metabolic rate of oxygen","volume":"40","author":"Klee","year":"1964","journal-title":"Acta Neurologica Scandinavica"},{"key":"S0007125000092369_ref56","first-page":"85","volume-title":"Brain and Blood Flow","author":"Sveinsdottir","year":"1971"},{"key":"S0007125000092369_ref22","article-title":"The inert gas intra-arterial injection method for determining regional cerebral blood flow through the intact skull","volume":"18","author":"H\u2298edt-Rasmussen","year":"1966","journal-title":"Circulation Research"},{"key":"S0007125000092369_ref41","volume-title":"Higher Cortical Functions in Man.","author":"Luria","year":"1966"},{"key":"S0007125000092369_ref9","volume-title":"Manual for the Examination of Aphasic and Related Disturbances.","author":"Eisenson","year":"1954"},{"key":"S0007125000092369_ref16","first-page":"37","article-title":"Emotional behaviour, personality changes and cognitive reduction in presenile dementia: related to regional cerebral blood flow","volume":"257","author":"Gustafson","year":"1975","journal-title":"Acta Psychiatrica Scandinavica."},{"key":"S0007125000092369_ref54","volume-title":"Morbus Alzheimer and Morbus Pick. A Genetic, Clinical and Patho-anatomical Study.","author":"Sj\u00f6gren","year":"1952"},{"key":"S0007125000092369_ref30","article-title":"Cerebral complications following measurements of regional cerebral blood flow (rCBF) with the intra-arterial 133xenon injection method","volume":"4","author":"H\u2298edt-Rasmussen","year":"1973","journal-title":"Stroke"},{"key":"S0007125000092369_ref32","article-title":"Blood flow patterns induced in the dominant hemisphere by speech and reading","volume":"97","author":"H\u2298edt-Rasmussen","year":"1974","journal-title":"Brain"},{"key":"S0007125000092369_ref1","article-title":"An experiment in the measurement of mental deterioration","volume":"117","author":"Babcock","year":"1930","journal-title":"Archives of Psychology"},{"key":"S0007125000092369_ref55","volume-title":"Psychopathologic behavior in a serial experiment: investigations of neurotic, psychotic, psychopathic and normal subjects. (Lunds Universitets \u00e5rsskrift, N.F., avd 2, Bd. 56, nr 5)","author":"Smith","year":"1959"},{"key":"S0007125000092369_ref6","volume-title":"Handbook of Aging and the Individual","author":"Busse","year":"1967"},{"key":"S0007125000092369_ref23","unstructured":"Hus\u00e9n T. (1956) CBV-skalan, individuell testskala f\u00f6r vuxna. Lund."},{"key":"S0007125000092369_ref35","volume-title":"Handbook of Aging and the Individual","author":"Jones","year":"1967"},{"key":"S0007125000092369_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1959.03840040001001"},{"key":"S0007125000092369_ref46","volume-title":"American Handbook of Psychiatry, II","author":"Mulder","year":"1959"},{"key":"S0007125000092369_ref38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104063"},{"key":"S0007125000092369_ref28","first-page":"195","article-title":"Increase of regional cerebral blood flow during mental effort in normals and patients with focal brain disorders","volume":"3","author":"H\u2298edt-Rasmussen","year":"1967","journal-title":"Experimental Brain Research"},{"key":"S0007125000092369_ref26","article-title":"Normal values of regional cerebral blood flow in man, including flow and weight estimates of grey and white matter. A preliminary summary","volume":"41","author":"Ingvar","year":"1965","journal-title":"Acta Neurologica Scandinavica"},{"key":"S0007125000092369_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/8.2.137"},{"key":"S0007125000092369_ref24","doi-asserted-by":"publisher","DOI":"10.1037\/h0042353"},{"key":"S0007125000092369_ref57","doi-asserted-by":"publisher","DOI":"10.1159\/000114498"},{"key":"S0007125000092369_ref25","volume-title":"Brain Work","author":"Ingvar","year":"1975"},{"key":"S0007125000092369_ref34","volume-title":"Brain Work.","author":"Ingvar","year":"1975"},{"key":"S0007125000092369_ref29","first-page":"42","article-title":"Regional cerebral blood flow in organic dementia with early onset","volume":"41","author":"H\u2298edt-Rasmussen","year":"1970","journal-title":"Acta Neurologica Scandinavica"},{"key":"S0007125000092369_ref50","article-title":"Patterns of activation in the grey matter of the dominant hemisphere during memorization and reasoning: a study of regional cerebral blood flow changes during psychological testing in a group of neurologically normal subjects","volume":"96","author":"Risbero","year":"1973","journal-title":"Brain"},{"key":"S0007125000092369_ref2","unstructured":"Baer P. E. , Mathew N. T. & FAIBISH G. M. (1975) Neuro-physiological correlates of hemispheric and regional cerebral blood flow in dementia. VII Salzburg Conference on Cerebrovascular Disease. September 1974. To be published."},{"key":"S0007125000092369_ref31","unstructured":"H\u2298edt-Rasmussen K. & Franz\u00e9n G. (1974) Distribution of cerebral activity in chronic schizophrenia. Lancet, December 21, 1484\u20145."},{"key":"S0007125000092369_ref33","volume-title":"CIBA Symposium: Outcome of Severe CNS Damage.","author":"Ingvar","year":"1975"},{"key":"S0007125000092369_ref43","first-page":"379","volume-title":"The Parietal Lobes","author":"Mayer-Gross","year":"1953"},{"key":"S0007125000092369_ref36","volume-title":"Mental Disorders in Later Life.","author":"Kaplan","year":"1956"},{"key":"S0007125000092369_ref4","unstructured":"Berglund M. & Sonesson B. Personality impairment in chronic alcoholism and its relation to regional cerebral blood flow and psychometric performance. Journal of Studies on Alchohol. Submitted for publication."},{"key":"S0007125000092369_ref40","first-page":"376","article-title":"Radioisotopic assessment of regional cerebral blood flow","volume":"1","author":"Cronqvist","year":"1972","journal-title":"Progress in Nuclear Medicine"},{"key":"S0007125000092369_ref42","unstructured":"Mansvelt J. van (1954) Pick's Disease: a syndrome of lobar, cerebral atrophy; its clinical-anatomical and histopathological types. Thesis. Enschede, Utrecht."},{"key":"S0007125000092369_ref12","unstructured":"Franzen G. & Ingvar D. H. Abnormal distribution of cerebral activity in chronic schizophrenia. Journal of Psychiatric Research. In press."},{"key":"S0007125000092369_ref11","first-page":"151","article-title":"Qualitative differences in the vocabulary responses of normals and abnormals","volume":"39","author":"Feifel","year":"1949","journal-title":"Genetic Psychology Monographs"},{"key":"S0007125000092369_ref21","volume-title":"Regional cerebral blood flow. The intra-arterial injection method","author":"H\u2298edt-Rasmussen","year":"1967"},{"key":"S0007125000092369_ref15","first-page":"7","article-title":"Psychiatric symptoms in dementia with onset in the presenile period","volume":"257","author":"Gustafson","year":"1975","journal-title":"Acta Psychiatrica Scandinavica."},{"key":"S0007125000092369_ref39","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.13.9.719"},{"key":"S0007125000092369_ref53","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/94.2.273"},{"key":"S0007125000092369_ref51","doi-asserted-by":"crossref","DOI":"10.1192\/bjp.99.416.439","article-title":"Psychological test performance in patients over 60. I. Senile psychosis and the affective disorders of old age","volume":"99","author":"Roth","year":"1953","journal-title":"Journal of Mental Science"},{"key":"S0007125000092369_ref3","volume-title":"The Revised Visual Retention Test. Clinical and Experimental Applications.","author":"Benton","year":"1963"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000092369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:11:45Z","timestamp":1559077905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000092369\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,3]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,3]]}},"alternative-id":["S0007125000092369"],"URL":"https:\/\/doi.org\/10.1192\/bjp.128.3.209","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,3]]}}}