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Symptoms arose at varying times after the start of lithium therapy; in no patient did symptoms antedate the use of the drug.<\/jats:p><jats:p>Plasma levels of antidiuretic hormone were found, on average, to be higher than in normal control subjects for a given level of plasma osmolality, although the scatter of results was wide. It is suggested that elevation of antidiuretic hormone occurs as a compensatory mechanism for the polyuria which is a common feature of long-term lithium treatment. The more florid form of nephrogenic diabetes insipidus occasionally seen in lithium takers seems likely to be due to a different mechanism from the more common mild polyuria.<\/jats:p>","DOI":"10.1192\/bjp.130.2.144","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"144-147","source":"Crossref","is-referenced-by-count":34,"title":["Plasma Levels of Antidiuretic Hormone in Patients Receiving Prolonged Lithium Therapy"],"prefix":"10.1192","volume":"130","author":[{"given":"P. L.","family":"Padfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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