{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:22:29Z","timestamp":1756995749850},"reference-count":31,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":14972,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1977,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Reported reductions in the activity of platelet monoamine oxidase (MAO) in chronic schizophrenic patients might be contributed to by alterations in hormones, platelet numbers or other non-specific factors thought to affect enzyme activity. In this study, MAO activity in 27 patients with chronic schizophrenia was measured, using benzylamine as the substrate in an assay based on platelet counts instead of platelet protein, and was found to be markedly lower than mean MAO activity in 375 normal controls. These results were similar to those previously reported with tryptamine as a substrate for the enzyme. Serum testosterone, triiodothyronine, iron and iron-binding capacity were within normal ranges in individuals with reduced MAO activity, and none of these measurements was significantly correlated with MAO activities. Platelet MAO activity remained stable over time in patients and controls.<\/jats:p>","DOI":"10.1192\/bjp.130.2.151","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"151-158","source":"Crossref","is-referenced-by-count":28,"title":["Monoamine Oxidase in Chronic Schizophrenia"],"prefix":"10.1192","volume":"130","author":[{"given":"Dennis L.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Belmaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000011843_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(74)90097-1"},{"key":"S0007125000011843_ref4","article-title":"An improved radioimmunoassay of triidothyronine in serum: its application to clinical and physiological studies","volume":"80","author":"Chopra","year":"1972","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0007125000011843_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/253659b0"},{"key":"S0007125000011843_ref20","unstructured":"Murphy D. L. , Wright C. , Buchsbaum M. , Nichols A. , Costa J. L. & Wyatt R. J. (in press) Platelet and plasma amine oxidase activity in 680 normals: sex and age differences and stability over time. Biochem. med."},{"key":"S0007125000011843_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90058-0"},{"key":"S0007125000011843_ref21","first-page":"59","volume-title":"Neuropsychopharmacology of Monoamines and Their Regulatory Enzymes","author":"Nies","year":"1974"},{"key":"S0007125000011843_ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000122174"},{"key":"S0007125000011843_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1974.tb09210.x"},{"key":"S0007125000011843_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92301-6"},{"key":"S0007125000011843_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/238225a0"},{"key":"S0007125000011843_ref28","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4076.916"},{"key":"S0007125000011843_ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197509000-00005"},{"key":"S0007125000011843_ref6","article-title":"Decreased blood platelet MAO activity in unmediated chronic schizophrenic patients","volume":"133","author":"Domino","year":"1976","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000011843_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(72)90024-8"},{"key":"S0007125000011843_ref16","doi-asserted-by":"publisher","DOI":"10.1021\/ac60149a611"},{"key":"S0007125000011843_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700056701"},{"key":"S0007125000011843_ref19","volume-title":"The Biology of the Major Psychoses: A Comparative Analysis","author":"Murphy","year":"1975"},{"key":"S0007125000011843_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760160093019"},{"key":"S0007125000011843_ref2","doi-asserted-by":"crossref","unstructured":"Brambilla F. & Penati G. (1970) Hormones and behavior in Schizophrenia. In Influence of Hormones on the Nervous System, Proc. Int. Soc. Psychoneuroendocrinology, pp 482\u201394, Brooklyn.","DOI":"10.1159\/000392246"},{"key":"S0007125000011843_ref3","article-title":"Platelet monoamine oxidase activity in acute schizophrenia","volume":"132","author":"Carpenter","year":"1975","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000011843_ref8","doi-asserted-by":"crossref","DOI":"10.1176\/ajp.1974.131.12.1392","article-title":"Blood platelet MAO activity in psychiatric patients","volume":"131","author":"Friedman","year":"1974","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000011843_ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-22-12-1242"},{"key":"S0007125000011843_ref15","article-title":"Platelet monoamine oxidase activity and substrate preferences in schizophrenia patients","volume":"7","author":"Meltzer","year":"1974","journal-title":"Research Communications in Chemical Pathology and Pharmacology"},{"key":"S0007125000011843_ref22","unstructured":"Redmond D. E. , Baulu J. , Murphy D. L. , Loriaux D. L. , Ziegler M. G. & Lake C. R. (in press) Effects of testosterone on plasma and platelet monoamine oxidase and plasma dopamine \u03b2-hydroxylase activities in the male rhesus monkey. Psychosomatic Medicine."},{"key":"S0007125000011843_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1971.01750120052009"},{"key":"S0007125000011843_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(63)90211-9"},{"key":"S0007125000011843_ref10","article-title":"The effect of adrenaline on human platelet MAO","volume":"44","author":"Gentil","year":"1975","journal-title":"Psychopharmocologia"},{"key":"S0007125000011843_ref29","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/17.9.950","article-title":"An autoanalyzer procedure for serum iron and total iron-binding capacity, with use of ferrozine","volume":"17","author":"Yee","year":"1971","journal-title":"Clinical Chemistry"},{"key":"S0007125000011843_ref7","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1968"},{"key":"S0007125000011843_ref30","article-title":"Human platelet monoamine oxidase activity in iron-deficiency anaemia","volume":"48","author":"Youdim","year":"1975","journal-title":"Clinical Science and Molecular Medicine"},{"key":"S0007125000011843_ref12","doi-asserted-by":"publisher","DOI":"10.1139\/o67-042"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000011843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T16:29:16Z","timestamp":1588868956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000011843\/type\/journal_article"}},"subtitle":["Studies of Hormonal and other Factors affecting Enzyme Activity"],"short-title":[],"issued":{"date-parts":[[1977,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,2]]}},"alternative-id":["S0007125000011843"],"URL":"https:\/\/doi.org\/10.1192\/bjp.130.2.151","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,2]]}}}