{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:18:28Z","timestamp":1792192708006,"version":"4.4.0"},"reference-count":19,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":14883,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1977,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fifty-three psychiatric patients who had been receiving treatment with lithium continuously for more than two years were examined to estimate the prevalence of lithium-induced hypothyroidism. It was found to be 20 per cent among women. No men were affected among these patients. In order to study the characteristics of the disorder further cases were drawn from another population. One third of the patients developed hypothyroidism during their first year of treatment, others not until after 9 years. About two thirds of the female patients with hypothyroidism had thyroid antibodies. All cases with lithium-induced hypothyroidism showed elevated levels of serum thyrotropin, which in our experience is the laboratory examination of choice in these as well as other cases of \u2018primary\u2019 hypothyroidism. Since the probability of detecting these cases at a given control visit was found to be low, we feel that such visits need not include extensive laboratory investigations. Hypothyroid patients responding well to lithium treatment should continue their medication combined with appropriate thyroxine substitution.<\/jats:p>","DOI":"10.1192\/bjp.130.5.452","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T18:35:43Z","timestamp":1218566143000},"page":"452-458","source":"Crossref","is-referenced-by-count":68,"title":["On the Prevalence, Diagnosis and Management of Lithium-Induced Hypothyroidism in Psychiatric Patients"],"prefix":"10.1192","volume":"130","author":[{"given":"G\u00f6ran","family":"Lindstedt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-\u00c5ke","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Walinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Skott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"\u00d6hman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000012691_ref12","article-title":"Occurrence of goitre during lithium treatment","volume":"iii","author":"Schou","year":"1968","journal-title":"British Medical Journal"},{"key":"S0007125000012691_ref1","first-page":"587","article-title":"Quantitative studies of immunofluorescent staining","volume":"39","author":"Beutner","year":"1968","journal-title":"Bulletin of the World Health Organization"},{"key":"S0007125000012691_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(74)90031-4"},{"key":"S0007125000012691_ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-36-6-1251"},{"key":"S0007125000012691_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700049631"},{"key":"S0007125000012691_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(69)90035-2"},{"key":"S0007125000012691_ref15","article-title":"Effects of lithium on thyroid function","volume":"31","author":"Shopsin","year":"1970","journal-title":"Diseases of the Nervous System"},{"key":"S0007125000012691_ref2","article-title":"Autoantikroppar i diagnostiken","volume":"65","author":"Biberfeld","year":"1968","journal-title":"L\u00e4kartidningen"},{"key":"S0007125000012691_ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-36-2-338"},{"key":"S0007125000012691_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1973.tb04416.x"},{"key":"S0007125000012691_ref8","doi-asserted-by":"crossref","DOI":"10.3109\/10408367109151311","volume-title":"The Use of Lithium in Psychiatry.","author":"Maletzky","year":"1971"},{"key":"S0007125000012691_ref9","unstructured":"Nosslin B. (1965) A simplified technique for the triiodothyronine test (T3 test) with Sephadex. Scandinavian Journal of Clinical and Laboratory Investigation, Suppl 86, 177."},{"key":"S0007125000012691_ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-35-6-905"},{"key":"S0007125000012691_ref18","article-title":"The use of lithium in Graves' disease","volume":"47","author":"Temple","year":"1972","journal-title":"Mayo Clinic Proceedings"},{"key":"S0007125000012691_ref19","first-page":"75","article-title":"The effect of lithium on thyroid in man","volume":"9","author":"Villeneuve","year":"1974","journal-title":"International Journal of Clinical Pharmacology"},{"key":"S0007125000012691_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1969.tb02045.x"},{"key":"S0007125000012691_ref10","article-title":"The use of a vertical illuminator with interchangeable dichroic mirrors for fluorescence microscopy with incident light","volume":"68","author":"Ploem","year":"1967","journal-title":"Zeitschrift f\u00fcr wissenschaftliche Mikroskopie und mikroskopische Technik"},{"key":"S0007125000012691_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(73)90357-4"},{"key":"S0007125000012691_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(68)90239-7"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000012691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:07:09Z","timestamp":1559056029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000012691\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,5]]}},"alternative-id":["S0007125000012691"],"URL":"https:\/\/doi.org\/10.1192\/bjp.130.5.452","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,5]]}}}