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All patients received an initial dose of 15 mg daily, increasing to 30 mg daily between the third and seventh day, but subsequently, using double-blind procedure, one group took the commonly prescribed dose of 45 mg daily and the other took 90 mg daily. Acetylator status was independently determined before the start of treatment. Each diagnostic group showed a similar response to treatment, but patients taking the higher dose improved significantly more than those taking normal dosage, and the rate of improvement, measured by weekly self-ratings, was also more rapid with higher dosage. Acetylator status did not affect clinical response. The results suggest that dosage is more important in determining clinical response to phenelzine in neurotic disorder than specific diagnosis or acetylator status.<\/jats:p>","DOI":"10.1192\/bjp.136.4.359","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T18:35:43Z","timestamp":1218566143000},"page":"359-365","source":"Crossref","is-referenced-by-count":39,"title":["Clinical and Pharmacokinetic Factors Affecting Response to Phenelzine"],"prefix":"10.1192","volume":"136","author":[{"given":"Peter","family":"Tyrer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lambourn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervyn","family":"Whitford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000045712_ref32","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.128.4.354"},{"key":"S0007125000045712_ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6039.817"},{"key":"S0007125000045712_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422146"},{"key":"S0007125000045712_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb04593.x"},{"key":"S0007125000045712_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.6.4.405"},{"key":"S0007125000045712_ref26","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.130.5.432"},{"key":"S0007125000045712_ref9","article-title":"Acetylator status and response to phenelzine in depressed patients","volume":"i","author":"Johnstone","year":"1973","journal-title":"Lancet"},{"key":"S0007125000045712_ref19","article-title":"A controlled trial of phenelzine in the treatment of severe depressive illness","volume":"107","author":"Rees","year":"1961","journal-title":"Journal of Mental Science"},{"key":"S0007125000045712_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.4.314"},{"key":"S0007125000045712_ref4","article-title":"The influence of acetylator phenotype on the effects of treating depression with phenelzine","volume":"6","author":"Evans","year":"1965","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"S0007125000045712_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00421708"},{"key":"S0007125000045712_ref23","volume-title":"Ph.D.","author":"Salkind","year":"1973"},{"key":"S0007125000045712_ref22","first-page":"34","article-title":"Anxiety neurosis in general practice","volume":"48","author":"Salkind","year":"1972","journal-title":"Postgraduate Medical Journal"},{"key":"S0007125000045712_ref25","article-title":"Simplified method for determining acetylator phenotype","volume":"iii","author":"Schroder","year":"1972","journal-title":"British Medical Journal"},{"key":"S0007125000045712_ref1","article-title":"Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression","volume":"135","author":"Davidson","year":"1978","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000045712_ref5","unstructured":"Fullerton A. 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