{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:31:11Z","timestamp":1774686671247,"version":"3.50.1"},"reference-count":25,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":13664,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1980,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This retrospective study, based on 18 case reports, describes an organic affective syndrome, manic type, occurring shortly after the initiation of thyroid replacement in hypothyroid patients. The symptomatology and homogeneity of the syndrome offers insight into the relationship between thyroid activity and affective disturbance. The patients experiencing mania showed concurrent psychopathology at the time of replacement therapy, frequently had a past history of personal or familial psychiatric disorder and were given dosages in the high range of normal. The potential morbidity of the manic state was considerable. These findings suggest that a group of hypothyroid patients at risk can be identified. In such a group, lower initial dosages and gradual increases in dosage may be indicated.<\/jats:p>","DOI":"10.1192\/bjp.137.3.222","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T22:35:43Z","timestamp":1218580543000},"page":"222-228","source":"Crossref","is-referenced-by-count":57,"title":["Thyroid-Induced Mania in Hypothyroid Patients"],"prefix":"10.1192","volume":"137","author":[{"given":"Allan M.","family":"Josephson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000105379_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4893.891"},{"key":"S0007125000105379_ref24","volume-title":"Symposium of the International Society of Psychoneuroendocrinology","author":"Stolk","year":"1975"},{"key":"S0007125000105379_ref15","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.91.6.1263"},{"key":"S0007125000105379_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1966.01730090053008"},{"key":"S0007125000105379_ref21","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.126.4.457"},{"key":"S0007125000105379_ref8","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.3.219"},{"key":"S0007125000105379_ref6","article-title":"The \u2018switch process' in manic depressive illness","volume":"27","author":"Bunney","year":"1972","journal-title":"Archives of General Psychiatry"},{"key":"S0007125000105379_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760210019001"},{"key":"S0007125000105379_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-193601000-00003"},{"key":"S0007125000105379_ref4","volume-title":"The Pharmacological Basis of Therapeutics (5th ed.)","author":"Astwood","year":"1975"},{"key":"S0007125000105379_ref10","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, Third Edition","year":"1978"},{"key":"S0007125000105379_ref5","article-title":"Cerebral metabolic disturbances in hypothyroidism","volume":"93","author":"Browning","year":"1954","journal-title":"Archives of Internal Medicine"},{"key":"S0007125000105379_ref23","first-page":"1","article-title":"Rational therapy in hypothyroidism","volume":"10","author":"Ridgway","year":"1976","journal-title":"Rational Drug Therapy"},{"key":"S0007125000105379_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4636.1112-a"},{"key":"S0007125000105379_ref19","first-page":"276","volume-title":"Thyroid and Its Diseases","author":"Means","year":"1948"},{"key":"S0007125000105379_ref12","article-title":"A psychiatric study of hypothyroidism","volume":"5","author":"Jain","year":"1972","journal-title":"Psychiatric Clinica"},{"key":"S0007125000105379_ref25","article-title":"Psychosis associated with myxoedema","volume":"11","author":"Ziegler","year":"1931","journal-title":"Journal of Neurology and Psychopathology"},{"key":"S0007125000105379_ref14","article-title":"Appearance of manic psychosis following rapid normalization of thyroid status","volume":"136","author":"Josephson","year":"1979","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000105379_ref16","volume-title":"Foundations of Behavioral Research.","author":"Kerlinger","year":"1973"},{"key":"S0007125000105379_ref9","article-title":"Drug therapy reviews: Management of hypothyroidism","volume":"35","author":"Cobb","year":"1978","journal-title":"American Journal of Hospital Pharmacy"},{"key":"S0007125000105379_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)92700-9"},{"key":"S0007125000105379_ref18","volume-title":"The Thyroid","author":"Lidz","year":"1971"},{"key":"S0007125000105379_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02096.x"},{"key":"S0007125000105379_ref17","volume-title":"Advances in Neurology","volume":"vol. 5","author":"Klawans","year":"1974"},{"key":"S0007125000105379_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31964-2"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000105379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T21:38:27Z","timestamp":1558820307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000105379\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,9]]}},"alternative-id":["S0007125000105379"],"URL":"https:\/\/doi.org\/10.1192\/bjp.137.3.222","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9]]}}}