{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:02:42Z","timestamp":1756461762269},"reference-count":16,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":13330,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A pair of monozygotic twins, one suffering from the Wernicke-Korsakoff syndrome, verified at autopsy, and the other healthy, was studied biochemically. The erythrocyte transketolase of each twin showed abnormalities, though these differed in the two individuals. In the healthy twin, the basal transketolase was low, but responded normally to thiamine pyrophosphate (TPP) added<jats:italic>in vitro.<\/jats:italic>In the twin with the Wernicke-Korsakoff syndrome the basal level of the enzyme and its response<jats:italic>in vitro<\/jats:italic>were normal, but a period of treatment with thiamine tetrahydrofurfuryldisulphide, led to loss of the<jats:italic>in vitro<\/jats:italic>response. It is suggested that, initially, an inborn error of metabolism may have been common to both twins.<\/jats:p>","DOI":"10.1192\/bjp.139.2.156","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T23:20:52Z","timestamp":1218583252000},"page":"156-159","source":"Crossref","is-referenced-by-count":15,"title":["Wernicke-Korsakoff Syndrome in Monozygotic Twins: A Biochemical Peculiarity"],"prefix":"10.1192","volume":"139","author":[{"given":"Denis","family":"Leigh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Mcburney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Mcllwain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000133355_ref14","volume-title":"Psychotic and Neurotic Illnesses in Twins.","author":"Slater","year":"1953"},{"key":"S0007125000133355_ref13","volume-title":"Alcoholism. New Knowledge and New Responses","author":"Shields","year":"1977"},{"key":"S0007125000133355_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/adc.55.10.789"},{"key":"S0007125000133355_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1941.02280220002001"},{"key":"S0007125000133355_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(70)90361-8"},{"key":"S0007125000133355_ref8","article-title":"Restoration thiamine of neuromuscular transmission","volume":"32","author":"Eichenbaum","year":"1971","journal-title":"Brain Research"},{"key":"S0007125000133355_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196209202671204"},{"key":"S0007125000133355_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712222972503"},{"key":"S0007125000133355_ref16","unstructured":"Waldenlind L. (1978) Studies on thiamine and neuromuscular transmission. Acta Physiologica Scandinavica (Supp) 459."},{"key":"S0007125000133355_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/22.1.44"},{"key":"S0007125000133355_ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3875.74"},{"key":"S0007125000133355_ref3","doi-asserted-by":"crossref","DOI":"10.1111\/j.1749-6632.1962.tb30574.x","article-title":"Erythrocyte transketolase in early thiamine deficiency","volume":"98","author":"Brin","year":"1962","journal-title":"Annals of the New York Academy of Science"},{"key":"S0007125000133355_ref4","first-page":"468","article-title":"Human thiamine deficiency and erythrocyte transketolase (abstract)","volume":"21","author":"Brin","year":"1962","journal-title":"Federation Proceedings"},{"key":"S0007125000133355_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-193911000-00001"},{"key":"S0007125000133355_ref9","doi-asserted-by":"crossref","DOI":"10.1097\/00007611-193106000-00028","volume-title":"Inborn Factors in Disease.","author":"Garrod","year":"1931"},{"key":"S0007125000133355_ref15","volume-title":"The Wernicke\u2014Korsakoff Syndrome.","volume":"7","author":"Victor","year":"1971"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000133355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T07:04:45Z","timestamp":1709190285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000133355\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,8]]}},"alternative-id":["S0007125000133355"],"URL":"https:\/\/doi.org\/10.1192\/bjp.139.2.156","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8]]}}}