{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:58:17Z","timestamp":1772423897858,"version":"3.50.1"},"reference-count":18,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":12812,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Of 26 patients with active Cushing's syndrome assessed before and at three and 12 months after treatment, 21 had pituitary-dependent disease. Median urinary free Cortisol values (per 24 hours) were 680, 180 and 200 nmol at zero, three and 12 months (normal &lt;270 nmol), with significant improvement (P &lt;0.001) at three and 12 months. Depression on the Hamilton rating scale was significantly less at three months (P &lt;0.01) and at 12 months (P &lt;0.001). We have already demonstrated that some patients with Cushing's syndrome have PSE diagnoses of depression and are more depressed than patients with other pituitary tumours. This is the firmest evidence to date that when Cushing's syndrome occurs it commonly causes depressive illness.<\/jats:p>","DOI":"10.1192\/bjp.142.1.16","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T23:20:52Z","timestamp":1218583252000},"page":"16-19","source":"Crossref","is-referenced-by-count":91,"title":["Cushing's Syndrome and Depression\u2014A Prospective Study of 26 Patients"],"prefix":"10.1192","volume":"142","author":[{"given":"William F.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"Checkley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Mashiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000113923_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"S0007125000113923_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1952.02320150016002"},{"key":"S0007125000113923_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/286608a0"},{"key":"S0007125000113923_ref8","article-title":"The determination of tryptophan in plasma, liver and urine","volume":"69","author":"Denckla","year":"1967","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0007125000113923_ref7","article-title":"The basophil adenomas of the pituitary gland and their clinical manifestations (pituitary basophilism)","volume":"50","author":"Cushing","year":"1932","journal-title":"Bulletin of the Johns Hopkins Medical School"},{"key":"S0007125000113923_ref4","volume-title":"Amphetamine Psychosis.","author":"Connell","year":"1958"},{"key":"S0007125000113923_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb07155.x"},{"key":"S0007125000113923_ref6","article-title":"Psychiatric disturbances associated with disorders of the ductless glands","volume":"69","author":"Cushing","year":"1913","journal-title":"American Journal of Insanity"},{"key":"S0007125000113923_ref16","volume-title":"Non-Parametric Statistics for the Behavioral Sciences.","author":"Siegel","year":"1956"},{"key":"S0007125000113923_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/74.1.72"},{"key":"S0007125000113923_ref10","doi-asserted-by":"publisher","DOI":"10.1038\/255170a0"},{"key":"S0007125000113923_ref14","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.136.2.125"},{"key":"S0007125000113923_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/2201095a0"},{"key":"S0007125000113923_ref13","article-title":"Psychiatric manifestations of Cushing's syndrome: Response to lowering of plasma Cortisol","volume":"191","author":"Jeffcoate","year":"1979","journal-title":"Quarterly Journal of Medicine"},{"key":"S0007125000113923_ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-51-1-1","article-title":"Cushing's Syndrome: clinical differential diagnosis and complications","volume":"51","author":"Hurxthal","year":"1959","journal-title":"Annals of Internal Medicine"},{"key":"S0007125000113923_ref1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0420079"},{"key":"S0007125000113923_ref3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.136.2.120"},{"key":"S0007125000113923_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb04298.x"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000113923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T20:05:23Z","timestamp":1558728323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000113923\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["S0007125000113923"],"URL":"https:\/\/doi.org\/10.1192\/bjp.142.1.16","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}