{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:32:14Z","timestamp":1756992734885},"reference-count":32,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"unspecified","delay-in-days":12539,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Review of 19 uncontrolled studies of antidepressants in phobic and in obsessive-compulsive disorders suggests that such drugs do not act reliably in the absence of symptoms of anxiety-depression (dysphoria). In dysphoric patients the drugs have a broad-spectrum effect not only reducing phobias and rituals but also anxiety-depression, panic, anger, and hostility, all of which are highly intercorrelated, but none yet demonstrated to be the core disturbance. Phobics, but not obsessive-compulsives, have an unusually high dropout rate from treatment when drugs or placebo are given. When antidepressants are stopped, even after 6\u20138 months, relapse is likely. The drugs do not reduce the liability of many phobics and obsessive-compulsives to have dysphoric episodes over the years. Exposure treatments are more lastingly effective for phobias and for rituals, but do not reduce the liability to later dysphoric episodes.<\/jats:p>","DOI":"10.1192\/bjp.143.4.338","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T19:20:52Z","timestamp":1218568852000},"page":"338-347","source":"Crossref","is-referenced-by-count":59,"title":["Are there Anticompulsive or Antiphobic Drugs? Review of the Evidence"],"prefix":"10.1192","volume":"143","author":[{"given":"Isaac","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"S0007125000200470_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-7009-3"},{"key":"S0007125000200470_ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207153070304"},{"key":"S0007125000200470_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422146"},{"key":"S0007125000200470_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00421708"},{"key":"S0007125000200470_ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780240079009"},{"key":"S0007125000200470_ref23","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.5.484"},{"key":"S0007125000200470_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.138.2.110"},{"key":"S0007125000200470_ref10","volume-title":"Living with Fear.","author":"Marks","year":"1978"},{"key":"S0007125000200470_ref20","first-page":"69","volume-title":"Anxiety: New Research and Changing Concepts","author":"McNair","year":"1981"},{"key":"S0007125000200470_ref19","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.1.11"},{"key":"S0007125000200470_ref7","first-page":"97","article-title":"Effects of psychotropic agents in high anxiety subjects","volume":"17","author":"Kahn","year":"1981","journal-title":"Psychopharmacology Bulletin"},{"key":"S0007125000200470_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790020047004"},{"key":"S0007125000200470_ref18","unstructured":"Mavissakalian M. et al (1983). In preparation."},{"key":"S0007125000200470_ref21","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.131.5.486"},{"key":"S0007125000200470_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02193476"},{"key":"S0007125000200470_ref32","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780140065007"},{"key":"S0007125000200470_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1971.01750150012002"},{"key":"S0007125000200470_ref13","first-page":"78","article-title":"Antidepressant drugs for phobias and rituals","volume":"18","author":"Marks","year":"1982a","journal-title":"Psychopharmacology Bulletin"},{"key":"S0007125000200470_ref26","article-title":"Phenelzine and exposure in the treatment of phobias","volume":"16","author":"Solyom","year":"1981","journal-title":"Biological Psychiatry"},{"key":"S0007125000200470_ref31","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770270057005"},{"key":"S0007125000200470_ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780140053006"},{"key":"S0007125000200470_ref22","volume-title":"Monoamine Oxidase Inhibitors\u2014State of the Art","author":"Nies","year":"1981"},{"key":"S0007125000200470_ref1","article-title":"Systematic studies with clomipramine in obsessive neurosis","volume":"2","author":"Ananth","year":"1980","journal-title":"Pharmaceutical Medicine"},{"key":"S0007125000200470_ref5","unstructured":"Ghosh A. , Marks I. M. & Carr A. C. (1983) Journal of the Royal Society of Medicine (in press)."},{"key":"S0007125000200470_ref11","volume-title":"Cure and Care of Neuroses.","author":"Marks","year":"1981"},{"key":"S0007125000200470_ref14","volume-title":"Stress in Psychiatric Disorders","author":"Marks","year":"1983"},{"key":"S0007125000200470_ref6","doi-asserted-by":"crossref","unstructured":"Insel T. , Murphy M. D. , Cohen R. M. , Allerman I. , Kilts C. , Linnoila M. (1983) Obsessive-compulsive disorder. A double blind trial of clomipramine and clorgyline. Archives of General Psychiatry. 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