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A target symptom scale of aggressiveness (TSA) and a clinical global impression scale of efficacy were rated at monthly intervals, and an extra-pyramidal side-effects scale weekly. The patients showed marked improvement during treatment with PP, which was assessed as superior to placebo. Individual and total TSA scores were also reduced compared to placebo.<\/jats:p>","DOI":"10.1192\/bjp.146.5.525","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T19:20:52Z","timestamp":1218568852000},"page":"525-529","source":"Crossref","is-referenced-by-count":18,"title":["Pipothiazine Palmitate in the Management of Aggressive Mentally Handicapped Patients"],"prefix":"10.1192","volume":"146","author":[{"given":"D. M.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L. 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