{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T14:11:13Z","timestamp":1725804673026},"reference-count":23,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":11324,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Patients with late paraphrenia were typed for HLA-A, -B and -C. Increased frequencies of BW55 (<jats:italic>P<\/jats:italic>= 0.036), B37 (<jats:italic>P<\/jats:italic>= 0.008) and CW6 (<jats:italic>P<\/jats:italic>=0.056) were found relative to controls. Unlike findings in paranoid schizophrenia, there was no HLAA9 association, suggesting that paraphrenics may be genetically distinct from schizophrenics. The primary association seems to be with B37, which has the lowest corrected <jats:italic>P<\/jats:italic> value and highest relative risk; if this were replicated, it would make possession of this antigen a strong risk factor for developing the disorder.<\/jats:p>","DOI":"10.1192\/bjp.150.1.124","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T19:43:23Z","timestamp":1218570203000},"page":"124-127","source":"Crossref","is-referenced-by-count":23,"title":["Genetic Markers in Late Paraphrenia: A Study of HLA Antigens"],"prefix":"10.1192","volume":"150","author":[{"given":"Mohsen","family":"Naguib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"McGuffm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilliard","family":"Festenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000214244_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"S0007125000214244_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700015889"},{"key":"S0007125000214244_ref20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.510.553"},{"key":"S0007125000214244_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1982.tb00344.x"},{"key":"S0007125000214244_ref15","first-page":"369","article-title":"Schizophrenia and schizophrenia like states in the elderly","volume":"7","author":"Kay","year":"1972","journal-title":"British Journal of Hospital Medicine"},{"key":"S0007125000214244_ref2","first-page":"831","article-title":"Hearing loss in paranoid and affective psychoses of the elderly","volume":"11","author":"Cooper","year":"1974","journal-title":"Lancet"},{"key":"S0007125000214244_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb05690.x"},{"key":"S0007125000214244_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(81)90041-X"},{"key":"S0007125000214244_ref9","first-page":"387","article-title":"Association and linkage studies of genetic marker loci in major psychiatric disorders","volume":"4","author":"Goldin","year":"1983","journal-title":"Psychiatric Developments"},{"key":"S0007125000214244_ref7","volume-title":"Histocompatibility Testing 1972","author":"Festenstein","year":"1973"},{"key":"S0007125000214244_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1963.tb07464.x"},{"key":"S0007125000214244_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1961.tb07362.x"},{"key":"S0007125000214244_ref12","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.113.498.461"},{"key":"S0007125000214244_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1974.tb00312.x"},{"key":"S0007125000214244_ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000117496"},{"key":"S0007125000214244_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(84)90054-4"},{"key":"S0007125000214244_ref18","volume-title":"Persistent Persecutory States of the Elderly","author":"Post","year":"1966"},{"key":"S0007125000214244_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1972.tb00767.x"},{"key":"S0007125000214244_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01285.x"},{"key":"S0007125000214244_ref21","first-page":"3","article-title":"HLA and disease association: a survey","volume":"22","author":"Svejgaard","year":"1975","journal-title":"Transplant Review"},{"key":"S0007125000214244_ref16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1192\/bjp.107.449.649","article-title":"Environmental and hereditary factors in the schizophrenia of old age (late paraphrenia) and their bearing on the general problem of causation in schizophrenia","volume":"107","author":"Kay","year":"1961","journal-title":"Journal of Mental Science"},{"key":"S0007125000214244_ref10","first-page":"239","article-title":"The epidemiologic approach to studies of association between HLA and disease. 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