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The cocaine users showed areas of deranged CBF as evidenced by patchy regions of defective isotope accumulation throughout their brain. The chronic cocaine users showed decreased relative CBF in the prefrontal cortex when compared with normal subjects. The repeated scans of some cocaine users, after 10 days of cocaine withdrawal, continued to show decreased relative CBF of the prefrontal cortex. We hypothesise that some of the widespread defects in CBF in the cocaine users could reflect the effects of vasospasm in cerebral arteries exposed chronically to the sympathomimetic actions of cocaine.<\/jats:p>","DOI":"10.1192\/bjp.152.5.641","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T19:43:23Z","timestamp":1218570203000},"page":"641-648","source":"Crossref","is-referenced-by-count":304,"title":["Cerebral Blood Flow in Chronic Cocaine Users: A Study with Positron Emission Tomography"],"prefix":"10.1192","volume":"152","author":[{"given":"Nora D.","family":"Volkow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Mullani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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