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There was no difference between the groups in plasma electrolytes or erect and supine blood pressures, arguing against secondary aldosteronism. In the lithium-treated group, there was a significant positive correlation between both PRA and plasma aldo<jats:italic>vs<\/jats:italic>serum lithium. We postulate that lithium inhibits the action of aldosterone on the distal tubule in the kidney. Activation of the renin angiotensin system maintains normal blood pressure and plasma electrolytes.<\/jats:p>","DOI":"10.1192\/bjp.153.2.205","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T23:43:23Z","timestamp":1218584603000},"page":"205-207","source":"Crossref","is-referenced-by-count":13,"title":["Lithium Carbonate \u2013 a Competitive Aldosterone Antagonist?"],"prefix":"10.1192","volume":"153","author":[{"given":"Paul M.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Atherden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R. 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