{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:35:14Z","timestamp":1782927314329,"version":"3.54.5"},"reference-count":12,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":10715,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>Adult hexosaminidase A deficiency is a form of GM<jats:sub>2<\/jats:sub> gangliosidosis with autosomal recessive inheritance. Only 35 cases (mostly among Ashkenazic Jews) have been reported worldwide. Symptoms include, in a third of the cases, psychosis. A 27\u2013year-old sufferer with no prior psychiatric history, developed a post-partum psychosis, with affective and hebephrenic components, 3 days following her first delivery. She responded to lithium within 10 days of initiating treatment; the full episode lasted 1 month. We conclude that lithium is the preferred treatment for psychosis in such adult patients, especially in light of possible long-term neurological deterioration caused by phenothiazines. Ashkenazic Jews with atypical neurological syndromes presenting with psychosis should be tested for hexosaminadase A deficiency.<\/jats:p>","DOI":"10.1192\/bjp.153.3.387","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T23:43:23Z","timestamp":1218584603000},"page":"387-389","source":"Crossref","is-referenced-by-count":25,"title":["Post-Partum Psychosis in Adult GM<sub>2<\/sub> Gangliosidosis"],"prefix":"10.1192","volume":"153","author":[{"given":"P.","family":"Lichtenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Navon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wertman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Dasberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000223076_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320240123"},{"key":"S0007125000223076_ref10","first-page":"1031","article-title":"Frequency of hexosaminidase A variant alleles among Ashkenazi Jews and prenatal diagnosis of GM2 gangliosidosis","volume":"37","author":"Navon","year":"1985","journal-title":"American Journal of Human Genetics"},{"key":"S0007125000223076_ref9","first-page":"287","article-title":"Apparent deficiency of hexosaminidase A in healthy members of a family with Tay Sachs disease","volume":"25","author":"Navon","year":"1973","journal-title":"American Journal of Human Genetics"},{"key":"S0007125000223076_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.5.662"},{"key":"S0007125000223076_ref5","first-page":"1238","volume-title":"Comprehensive Textbook of Psychiatry","author":"Kane","year":"1985"},{"key":"S0007125000223076_ref4","first-page":"444","article-title":"Estimation of the frequency of hexosaminidase A variant alleles in the American Jewish population","volume":"34","author":"Greenberg","year":"1982","journal-title":"American Journal of Human Genetics"},{"key":"S0007125000223076_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780320109013"},{"key":"S0007125000223076_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160105"},{"key":"S0007125000223076_ref1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1980"},{"key":"S0007125000223076_ref7","first-page":"49","volume-title":"Lysosomes in Applied Biology and Therapeutics","volume":"vol. 6","author":"Lullman-Rauch","year":"1979"},{"key":"S0007125000223076_ref12","first-page":"945","volume-title":"The Metabolic Basis of Inherited Diseases","author":"O'Brien","year":"1983"},{"key":"S0007125000223076_ref8","first-page":"182","article-title":"Postpartum psychosis as a discrete entity","volume":"46","author":"Munoz","year":"1985","journal-title":"Journal of Clinical Psychiatry"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000223076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T19:19:13Z","timestamp":1558379953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000223076\/type\/journal_article"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["S0007125000223076"],"URL":"https:\/\/doi.org\/10.1192\/bjp.153.3.387","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}