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Antidepressants have a broad-spectrum rather than specific anti-agoraphobia\/panic or anti-obsessive\u2013compulsive action. For long-term efficacy, there is good evidence for the value of exposure, but none for drugs. Because of relapse on ceasing drugs, and their side-effects, medication is less useful as the first line of treatment for chronic agoraphobia\/panic or obsessive-compulsive disorder than is the lastingly helpful approach of exposure. Antidepressants are worth trying when patients refuse or fail with exposure therapy, or are dysphoric.<\/jats:p>","DOI":"10.1192\/bjp.153.5.650","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T19:43:23Z","timestamp":1218570203000},"page":"650-658","source":"Crossref","is-referenced-by-count":62,"title":["Drugs and Psychological Treatments for Agoraphobia\/Panic and Obsessive\u2013Compulsive Disorders: A Review"],"prefix":"10.1192","volume":"153","author":[{"given":"Isaac","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000223702_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-198701000-00002"},{"key":"S0007125000223702_ref47","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.131.5.486"},{"key":"S0007125000223702_ref34","volume-title":"Fears, Phobias and Rituals","author":"Marks","year":"1987"},{"key":"S0007125000223702_ref33","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.143.4.338"},{"key":"S0007125000223702_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0364-7722(81)90077-1"},{"key":"S0007125000223702_ref51","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.5.484"},{"key":"S0007125000223702_ref65","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.127.2.163"},{"key":"S0007125000223702_ref63","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780240087010"},{"key":"S0007125000223702_ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800290073009"},{"key":"S0007125000223702_ref35","unstructured":"Marks I. 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