{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T14:53:21Z","timestamp":1649084001239},"reference-count":8,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":10473,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>Two cases of agranulocytosis occurring after addition of a butyrophenone to a course of phenothiazine treatment are reported and possible mechanisms for this interaction are discussed. Agranulocytosis is a well-documented adverse effect of phenothiazine administration (Vincent, 1986). Important factors are the total amount of drug given and the duration of administration. Agranulocytosis usually occurs within the first three months of therapy (Pisciotta, 1971; Marcus &amp; Mulvihill, 1978) and the relationship with the cumulative dose has been emphasised (Ananth <jats:italic>et al,<\/jats:italic> 1973). Agranulocytosis following prolonged administration has been rarely reported (Denber, 1970, Pisciotta, 1978). We report two cases where agranulocytosis developed in patients with a long previous exposure to phenothiazines, treated for the first time with a combination of phenothiazines and a butyrophenone.<\/jats:p>","DOI":"10.1192\/bjp.154.5.710","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:01:46Z","timestamp":1218585706000},"page":"710-712","source":"Crossref","is-referenced-by-count":7,"title":["Two Cases of Agranulocytosis on Addition of a Butyrophenone to a Long-Standing Course of Phenothiazine Treatment"],"prefix":"10.1192","volume":"154","author":[{"given":"Allan","family":"Young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kehoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000175579_ref2","article-title":"Parenteral droperidol for acutely disturbed behaviour in psychotic and non-psychotic individuals","volume":"15","author":"Ayd","year":"1980","journal-title":"International Drug Therapy Newsletter"},{"key":"S0007125000175579_ref7","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197815020-00003"},{"key":"S0007125000175579_ref4","first-page":"134","article-title":"An unusual case of chlorpromazine agranulocytosis","volume":"31","author":"Denber","year":"1970","journal-title":"Diseases of the Nervous System"},{"key":"S0007125000175579_ref8","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631010-00004"},{"key":"S0007125000175579_ref1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.130.1.100"},{"key":"S0007125000175579_ref5","first-page":"784","article-title":"Agranulocytosis and chlorpromazine","volume":"39","author":"Marcus","year":"1978","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000175579_ref3","volume-title":"Comprehensive Textbook of Psychiatry\/IV","author":"Davis","year":"1985"},{"key":"S0007125000175579_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cpt197112113"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000175579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T20:33:33Z","timestamp":1558298013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000175579\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,5]]}},"alternative-id":["S0007125000175579"],"URL":"https:\/\/doi.org\/10.1192\/bjp.154.5.710","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}