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Double-blind sequential discontinuation of fluvoxamine and pimozide confirmed that pimozide alone reduced only tics and the combination of fluvoxamine and pimozide was required for the improvement in OCD. Tics may reflect a subtype of OCD. Some OCD patients unresponsive to a 5\u2013HT reuptake inhibitor alone may benefit from the addition of a dopamine antagonist.<\/jats:p>","DOI":"10.1192\/bjp.157.5.762","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:13:05Z","timestamp":1218586385000},"page":"762-765","source":"Crossref","is-referenced-by-count":66,"title":["Fluvoxamine\/Pimozide Treatment of Concurrent Tourette's and Obsessive-Compulsive Disorder"],"prefix":"10.1192","volume":"157","author":[{"given":"Pedro L.","family":"Delgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne K.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Heninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.","family":"Charney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000046833_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810010038006"},{"key":"S0007125000046833_ref14","first-page":"31","article-title":"Imipramine treatment of panic disorder in a boy with Tourette's syndrome","volume":"49","author":"Sverd","year":"1988","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000046833_ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610163151604"},{"key":"S0007125000046833_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"S0007125000046833_ref13","volume-title":"In Biological Foundations of Psychiatry","author":"Shapiro","year":"1976"},{"key":"S0007125000046833_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800120066013"},{"key":"S0007125000046833_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198109000-00006"},{"key":"S0007125000046833_ref8","volume-title":"In Tourette Syndrome and Tic Disorders: Clinical Understanding and Treatment","author":"Leckman","year":"1988"},{"key":"S0007125000046833_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050316"},{"key":"S0007125000046833_ref2","volume-title":"In Advances in Experimental Medicine and Biology","author":"Gabay","year":"1981"},{"key":"S0007125000046833_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810180077011"},{"key":"S0007125000046833_ref9","first-page":"93","article-title":"Clomipramine vs. desipramine in childhood obsessive compulsive disorder","volume":"24","author":"Leonard","year":"1988","journal-title":"Psychopharmacology Bulletin"},{"key":"S0007125000046833_ref12","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1176\/ajp.145.9.1173a","article-title":"Fluoxetine treatment of obsessions and compulsions in patients with Tourette's syndrome","volume":"145","author":"Riddle","year":"1988","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000046833_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90135-9"},{"key":"S0007125000046833_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780240079009"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000046833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T19:52:54Z","timestamp":1558209174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000046833\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["S0007125000046833"],"URL":"https:\/\/doi.org\/10.1192\/bjp.157.5.762","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}