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These data indicate that TD response to clozapine is variable but that approximately 43% of cases, particularly those with dystonic features, improved after clozapine treatment. Methodological limitations of the studies described, however, preclude definitive conclusions, which must await appropriately controlled trials.<\/jats:p>","DOI":"10.1192\/bjp.158.4.503","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T17:25:27Z","timestamp":1224091527000},"page":"503-510","source":"Crossref","is-referenced-by-count":222,"title":["The Effects of Clozapine on Tardive Dyskinesia"],"prefix":"10.1192","volume":"158","author":[{"given":"Jeffrey A.","family":"Lieberman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce L.","family":"Saltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste A.","family":"Johns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simcha","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Borenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"S0007125000108487_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/BF00571412"},{"key":"S0007125000108487_ref7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1176\/ajp.136.3.317","article-title":"The trial use of clozapine for abnormal involuntary movement disorders","volume":"136","author":"Caine","year":"1979","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000108487_ref24","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.148.3.310"},{"key":"S0007125000108487_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90267-X"},{"key":"S0007125000108487_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb13094.x"},{"key":"S0007125000108487_ref21","first-page":"329","article-title":"Clozapine: guidelines for clinical management","volume":"50","author":"Lieberman","year":"1989a","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000108487_ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810100050009"},{"key":"S0007125000108487_ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1094449"},{"key":"S0007125000108487_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790320042006"},{"key":"S0007125000108487_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430090106"},{"key":"S0007125000108487_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290040069010"},{"key":"S0007125000108487_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"S0007125000108487_ref30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00421063","article-title":"Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesia. 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