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The mean age of onset of cognitive deficits in those for whom data are available (<jats:italic>n<\/jats:italic> = 11) is 47.6 (s.d. 3.0) years and the mean age of death (<jats:italic>n<\/jats:italic> = 10) is 58.8 (s.d. 4.0) years. The variability in the extent and quality of available data illustrates the diagnostic difficulties encountered in ascertaining such an extended pedigree, and the need for caution in interpreting the evidence.<\/jats:p>","DOI":"10.1192\/bjp.159.4.524","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T17:33:45Z","timestamp":1224092025000},"page":"524-530","source":"Crossref","is-referenced-by-count":9,"title":["A Family with Multiple Instances of Definite, Probable and Possible Early-Onset Alzheimer's Disease"],"prefix":"10.1192","volume":"159","author":[{"given":"H.","family":"Karlinsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Madrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ridgley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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