{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:48:44Z","timestamp":1757540924417},"reference-count":26,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":9224,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:p>The February 1992 issue of the <jats:italic>British Journal of Psychiatry<\/jats:italic> contained the summary report from the Second Phase of the Cross-National Collaborative Panic Study (CNCPS) on a clinical treatment trial of panic disorder. This manuscript was submitted in 1988 and took four years of response to critiques and revisions to generate a manuscript that was acceptable to the Editor of the <jats:italic>British Journal of Psychiatry.<\/jats:italic> In the same issue, Marks <jats:italic>et al<\/jats:italic> (1992) provided a \u2018Comment\u2019 which was critical of the study, calling it an \u201celephantine labour\u201d which \u201cresulted in the delivery of a mouse\u201d and was highly critical of the statistical analyses and interpretation. Moreover, their \u2018Comment\u2019 was a springboard for discussing general issues in the treatment of panic disorder and the relative value of pharmacological versus psychological treatments. In our opinion, the Marks <jats:italic>et al<\/jats:italic> \u2018Comment\u2019 is inaccurate and misleading. At many points, they make reference to topics being missing that are actually addressed to our manuscript and they presented a statistical summary in Table 1 (p. 203) of our data which was inaccurate. In this Comment, we address each item criticised.<\/jats:p>","DOI":"10.1192\/bjp.161.4.465","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:56:07Z","timestamp":1224032167000},"page":"465-471","source":"Crossref","is-referenced-by-count":24,"title":["Drug Treatment of Panic Disorder"],"prefix":"10.1192","volume":"161","author":[{"given":"Gerald L.","family":"Klerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000129691_ref25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207153070304"},{"key":"S0007125000129691_ref12","doi-asserted-by":"publisher","DOI":"10.1192\/pb.15.12.738"},{"key":"S0007125000129691_ref1","first-page":"301","article-title":"Alprazolam treatment for panic disorders","volume":"47","author":"Alexander","year":"1986","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000129691_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1991.tb03097.x"},{"key":"S0007125000129691_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(90)90108-3"},{"key":"S0007125000129691_ref26","first-page":"47","volume-title":"Anxiety: New Research and Changing Concepts","author":"Sheehan","year":"1981"},{"key":"S0007125000129691_ref8","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.2.191"},{"key":"S0007125000129691_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0007125000129691_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464571"},{"key":"S0007125000129691_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/026988118700100103"},{"key":"S0007125000129691_ref17","volume-title":"Fears, Phobias and Rituals.","author":"Marks","year":"1987a"},{"key":"S0007125000129691_ref5","volume-title":"Anxiety and its Disorders.","author":"Barlow","year":"1988"},{"key":"S0007125000129691_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800290027004"},{"key":"S0007125000129691_ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800290037005"},{"key":"S0007125000129691_ref9","first-page":"121","article-title":"Patients with panic disorder unaccompanied by depression improve with alprazolam and imipramine treatment","volume":"52","author":"Deltito","year":"1991","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000129691_ref11","doi-asserted-by":"publisher","DOI":"10.1192\/pb.15.11.682"},{"key":"S0007125000129691_ref23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1176\/ajp.148.4.517","article-title":"Controlled discontinuation of benzodiazepine treatment for patients with panic disorder","volume":"148","author":"Noyes","year":"1991","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000129691_ref2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1980"},{"key":"S0007125000129691_ref15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/archpsyc.1989.01810070096016","article-title":"In reply. 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