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Increased severity of symptoms and prominent diurnal changes were most evident in the panic-disorder patients with a history of depression. Although panic attacks were distributed throughout the 24\u2013hour period, patients with a current episode or history of depression tended to have more frequent panic attacks in the morning or early afternoon. These observations challenge the traditional belief that \u2018anxious neurotic\u2019 patients are relatively asymptomatic upon awakening in the morning and then develop more severe symptoms of anxiety later in the day.<\/jats:p>","DOI":"10.1192\/bjp.161.4.512","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:56:07Z","timestamp":1224032167000},"page":"512-516","source":"Crossref","is-referenced-by-count":15,"title":["Diurnal Rhythms and Symptom Severity in Panic Disorder"],"prefix":"10.1192","volume":"161","author":[{"given":"Marilla F.","family":"Geraci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Uhde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000129769_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"S0007125000129769_ref15","volume-title":"American Handbook of Psychiatry, Vol. VII; Advances and New Directions","author":"Wehr","year":"1981"},{"key":"S0007125000129769_ref14","volume-title":"Comprehensive Textbook of Psychiatry","volume":"I","author":"Uhde","year":"1989"},{"key":"S0007125000129769_ref12","first-page":"219","volume-title":"Neurobiology of Panic Disorder","author":"Uhde","year":"1990"},{"key":"S0007125000129769_ref10","volume-title":"State-Trait Anxiety (STAI) Manual.","author":"Spielberger","year":"1970"},{"key":"S0007125000129769_ref9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.121.2.147"},{"key":"S0007125000129769_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(86)90034-8"},{"key":"S0007125000129769_ref6","volume-title":"Schedule for Affective Disorders and Schizophrenia: Lifetime Version (Modified for the Study of Anxiety Disorders).","author":"Fyer","year":"1985"},{"key":"S0007125000129769_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(86)90072-8"},{"key":"S0007125000129769_ref2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1987"},{"key":"S0007125000129769_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198508000-00007"},{"key":"S0007125000129769_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1963.01720150090010"},{"key":"S0007125000129769_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(60)80026-0"},{"key":"S0007125000129769_ref11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0193-953X(18)30509-4","article-title":"Panic disorder and major depression: a tale of two syndromes","volume":"11","author":"Stein","year":"1988","journal-title":"Psychiatric Clinics of North America"},{"key":"S0007125000129769_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(85)90178-2"},{"key":"S0007125000129769_ref5","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.148.4.442"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000129769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T16:48:22Z","timestamp":1558025302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000129769\/type\/journal_article"}},"subtitle":["A Preliminary Study of 24\u2013Hour Changes in Panic Attacks, Generalised Anxiety, and Avoidance Behaviour"],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["S0007125000129769"],"URL":"https:\/\/doi.org\/10.1192\/bjp.161.4.512","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}