{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:21:02Z","timestamp":1779272462320,"version":"3.51.4"},"reference-count":35,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":9163,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>The aim of the present study was twofold: firstly, to determine cardiac vagal tone in subjects with generalised anxiety disorder directly, using an invasive pharmacological method; and secondly, to test whether the non-invasive method of measuring the amplitude of respiratory sinus arrhythmia (RSA) gives a reliable estimate of cardiac vagal tone in this form of anxiety disorder. Comparison of baseline physiological measures of anxious and control subjects revealed that cardiac vagal tone and heart rate were not different in the two groups of subjects, whereas length of the respiratory cycle and amplitude of respiratory sinus arrhythmia were reduced in the former group. Because of the higher respiratory rates of anxious subjects, the RSA method was found to underestimate cardiac vagal tone in generalised anxiety disorder.<\/jats:p>","DOI":"10.1192\/bjp.161.6.831","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T04:56:07Z","timestamp":1224046567000},"page":"831-835","source":"Crossref","is-referenced-by-count":39,"title":["Cardiac Vagal Tone in Generalised Anxiety Disorder"],"prefix":"10.1192","volume":"161","author":[{"given":"Mark","family":"Kollai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Kollai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000131046_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800250035006"},{"key":"S0007125000131046_ref35","doi-asserted-by":"publisher","DOI":"10.1037\/h0062429"},{"key":"S0007125000131046_ref25","volume-title":"Modern Trends in Psychosomatic Medicine","volume":"3","author":"Lum","year":"1976"},{"key":"S0007125000131046_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810120055009"},{"key":"S0007125000131046_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-197301000-00001"},{"key":"S0007125000131046_ref29","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-198601000-00003"},{"key":"S0007125000131046_ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790190045005"},{"key":"S0007125000131046_ref17","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.1952.9712829"},{"key":"S0007125000131046_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790300077010"},{"key":"S0007125000131046_ref23","volume-title":"Handbook of Biological Psychiatry, Part II: Brain Mechanisms and Abnormal Behavior\u2013Psychophysiology","author":"Lader","year":"1980"},{"key":"S0007125000131046_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790190025003"},{"key":"S0007125000131046_ref18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.39.5.801"},{"key":"S0007125000131046_ref3","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1987"},{"key":"S0007125000131046_ref30","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1176\/ajp.144.5.633","article-title":"Cardiac rate and rhythm in panic patients","volume":"144","author":"Shear","year":"1987","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000131046_ref4","volume-title":"Physiology.","author":"Berne","year":"1988"},{"key":"S0007125000131046_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790260038004"},{"key":"S0007125000131046_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(81)90082-5"},{"key":"S0007125000131046_ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000284079"},{"key":"S0007125000131046_ref33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1176\/ajp.143.4.478","article-title":"Ambulatory heart rate changes in patients with panic attacks","volume":"143","author":"Taylor","year":"1986","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000131046_ref19","volume-title":"Anxiety and Emotions.","author":"Kelly","year":"1980"},{"key":"S0007125000131046_ref32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1242\/jeb.100.1.109","article-title":"Central nervous integration of cardiovascular control","volume":"100","author":"Spyer","year":"1982","journal-title":"Journal of Experimental Biology"},{"key":"S0007125000131046_ref2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1980"},{"key":"S0007125000131046_ref6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.4.961"},{"key":"S0007125000131046_ref34","volume-title":"Statistical Principles in Experimental Design","author":"Winer","year":"1971"},{"key":"S0007125000131046_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1964.01720220060010"},{"key":"S0007125000131046_ref7","volume-title":"Manual of the Eysenck Personality Questionnaire.","author":"Eysenck","year":"1975"},{"key":"S0007125000131046_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1970.tb01753.x"},{"key":"S0007125000131046_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"S0007125000131046_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(56)90033-2"},{"key":"S0007125000131046_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0163-8343(87)90050-8"},{"key":"S0007125000131046_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1983.tb02156.x"},{"key":"S0007125000131046_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1982.tb00833.x"},{"key":"S0007125000131046_ref16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1176\/ajp.146.7.854","article-title":"Symptoms and treatment responses of generalized anxiety disorder patients with high versus low levels of cardiovascular complaints","volume":"146","author":"Hoehn-Saric","year":"1989b","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000131046_ref22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018070"},{"key":"S0007125000131046_ref31","volume-title":"Manual for the State-Trait Anxiety Inventory.","author":"Spielberger","year":"1970"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000131046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T13:32:16Z","timestamp":1631971936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000131046\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["S0007125000131046"],"URL":"https:\/\/doi.org\/10.1192\/bjp.161.6.831","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}