{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:38:58Z","timestamp":1791149938626,"version":"4.1.0"},"reference-count":151,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":8282,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>With genetic and neurochemical findings pointing to a biological aetiology, considerable effort has been devoted to finding direct evidence of brain abnormality in schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>T, MRI, post-mortem and functional imaging studies are reviewed to assess which structural and\/or functional brain abnormalities have been consistently demonstrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The only well-established structural abnormality in schizophrenia is lateral ventricular enlargement; this is modest and there is a large overlap with the normal population. There is no consensus on the presence of any localised structural abnormality from MRI and post-mortem studies, but the most promising findings concern temporal lobe limbic structures. Hypofrontality is not a well-replicated finding in schizophrenia under resting conditions, but the evidence is stronger for a selective association with negative symptoms. A number of studies have found hypofrontality under conditions of neuropsychological task activation. However, findings in these studies are divided and a recent methodologically sophisticated study has failed to confirm it, although this study suggested a decoupling of prefrontal and temporal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Schizophrenia is characterised by minor structural abnormality which, in the case of lateral ventricular enlargement, may be better understood as a risk factor than a causative lesion. The functional imaging findings are not transparent but suggest that, as a disorder, schizophrenia shows complex alterations in regional patterns of activity rather than any simple deficit in prefrontal function.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.166.5.563","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:31:20Z","timestamp":1224048680000},"page":"563-582","source":"Crossref","is-referenced-by-count":196,"title":["Schizophrenia \u2013 a Brain Disease? a Critical Review of Structural and Functional Cerebral Abnormality in the Disorder"],"prefix":"10.1192","volume":"166","author":[{"given":"S. E.","family":"Chua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000074511_ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1992.tb03216.x"},{"key":"S0007125000074511_ref151","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820030027004"},{"key":"S0007125000074511_ref142","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780070013001"},{"key":"S0007125000074511_ref138","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.5.687"},{"key":"S0007125000074511_ref133","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800300019002"},{"key":"S0007125000074511_ref150","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.158.2.158"},{"key":"S0007125000074511_ref130","volume-title":"Research Diagnostic Criteria for a Selected Group of Functional Disorders.","author":"Spitzer","year":"1978"},{"key":"S0007125000074511_ref128","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91601-6"},{"key":"S0007125000074511_ref144","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800310013001"},{"key":"S0007125000074511_ref126","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208273270905"},{"key":"S0007125000074511_ref125","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(93)90057-P"},{"key":"S0007125000074511_ref123","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700022303"},{"key":"S0007125000074511_ref122","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91254-8"},{"key":"S0007125000074511_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90289-P"},{"key":"S0007125000074511_ref149","volume-title":"The Ninth Revision of the International Statistical Classification of Diseases, Injuries and Causes of Death (ICD\u20139).","year":"1977"},{"key":"S0007125000074511_ref120","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1176\/ajp.151.6.842","article-title":"Decreased regional cortical gray matter volume in schizophrenia","volume":"151","author":"Schlaepfer","year":"1994","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref119","first-page":"101","article-title":"Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient","volume":"16","author":"Scheibel","year":"1981","journal-title":"Biological Psychiatry"},{"key":"S0007125000074511_ref117","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(90)90004-Q"},{"key":"S0007125000074511_ref114","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90020-3"},{"key":"S0007125000074511_ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120023005"},{"key":"S0007125000074511_ref109","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(92)90006-P"},{"key":"S0007125000074511_ref143","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800020020004"},{"key":"S0007125000074511_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790310046006"},{"key":"S0007125000074511_ref105","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230039007"},{"key":"S0007125000074511_ref108","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.1.16"},{"key":"S0007125000074511_ref102","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1176\/ajp.150.12.1849","article-title":"Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia","volume":"150","author":"Nestor","year":"1993","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref118","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810310036007"},{"key":"S0007125000074511_ref100","volume-title":"Schizophrenia and Related Syndromes.","author":"McKenna","year":"1994"},{"key":"S0007125000074511_ref99","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.5.593"},{"key":"S0007125000074511_ref98","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800300038004"},{"key":"S0007125000074511_ref87","doi-asserted-by":"publisher","DOI":"10.1159\/000115791"},{"key":"S0007125000074511_ref92","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.2.179"},{"key":"S0007125000074511_ref113","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.9.725"},{"key":"S0007125000074511_ref90","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1192\/S0007125000291824","article-title":"Computerised tomography in schizophrenia 15 years on","volume":"157","author":"Lewis","year":"1990","journal-title":"British Journal of Psychiatry"},{"key":"S0007125000074511_ref84","first-page":"325","volume-title":"Handbook of Schizophrenia, Vol. 1, The Neurology of Schizophrenia","author":"Kirch","year":"1986"},{"key":"S0007125000074511_ref83","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800300029003"},{"key":"S0007125000074511_ref81","doi-asserted-by":"publisher","DOI":"10.1007\/BF02190385"},{"key":"S0007125000074511_ref35","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810290025003"},{"key":"S0007125000074511_ref73","volume-title":"Abnormalities in Parents of Schizophrenics.","author":"Hirsch","year":"1975"},{"key":"S0007125000074511_ref111","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90142-4"},{"key":"S0007125000074511_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92525-0"},{"key":"S0007125000074511_ref116","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810350027004"},{"key":"S0007125000074511_ref129","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(87)90121-1"},{"key":"S0007125000074511_ref86","volume-title":"Dementia Praecox and Paraphrenia","author":"Kraepelin","year":"1913"},{"key":"S0007125000074511_ref74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1974.tb09707.x"},{"key":"S0007125000074511_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/17.4.597"},{"key":"S0007125000074511_ref148","doi-asserted-by":"publisher","DOI":"10.1126\/science.2878495"},{"key":"S0007125000074511_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90204-X"},{"key":"S0007125000074511_ref32","first-page":"251","volume-title":"The Neurology of Schizophrenia","author":"Coffman","year":"1986"},{"key":"S0007125000074511_ref134","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820070016003"},{"key":"S0007125000074511_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90295-5"},{"key":"S0007125000074511_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/14.1.21"},{"key":"S0007125000074511_ref94","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(94)90016-7"},{"key":"S0007125000074511_ref67","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170002537X"},{"key":"S0007125000074511_ref64","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810290019002"},{"key":"S0007125000074511_ref136","first-page":"147","article-title":"Elevated dopamine D2 receptor density in 23 schizophrenic patients: a positron emission tomography study with [11C]N-methylspiperone","volume":"6","author":"Tune","year":"1992","journal-title":"Schizophrenia Research"},{"key":"S0007125000074511_ref101","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700036667"},{"key":"S0007125000074511_ref50","doi-asserted-by":"publisher","DOI":"10.1007\/BF00380943"},{"key":"S0007125000074511_ref72","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950020040004"},{"key":"S0007125000074511_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230024005"},{"key":"S0007125000074511_ref103","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700020900"},{"key":"S0007125000074511_ref9","first-page":"634S","article-title":"Investigations of neuronal morphology and the neuronal cytoskeleton in the hippocampal region in schizophrenia","volume":"10","author":"Arnold","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"S0007125000074511_ref89","doi-asserted-by":"publisher","DOI":"10.1038\/353693a0"},{"key":"S0007125000074511_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120009003"},{"key":"S0007125000074511_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120031006"},{"key":"S0007125000074511_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700027434"},{"key":"S0007125000074511_ref106","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90549-H"},{"key":"S0007125000074511_ref137","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90167-4"},{"key":"S0007125000074511_ref76","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810340013002"},{"key":"S0007125000074511_ref55","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1991.0057"},{"key":"S0007125000074511_ref127","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1176\/ajp.150.9.1325","article-title":"Cortical\u2013striatal\u2013thalamic circuits and brain glucose metabolism in 70 unmedicated male schizophrenic patients","volume":"150","author":"Siegel","year":"1993","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref145","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb02933.x"},{"key":"S0007125000074511_ref54","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790140083010"},{"key":"S0007125000074511_ref79","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.6.736"},{"key":"S0007125000074511_ref95","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1176\/ajp.147.1.44","article-title":"Striatal D2 dopaminergic receptors assessed with positron emission tomography and 76Br bromospiperone in untreated schizophrenic patients","volume":"147","author":"Martinot","year":"1990","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(90)90004-P"},{"key":"S0007125000074511_ref132","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003223221201"},{"key":"S0007125000074511_ref12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1176\/ajp.147.11.1457","article-title":"Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia","volume":"147","author":"Barta","year":"1990","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref39","first-page":"93","volume-title":"Schizophrenia: Somatic Aspects","author":"David","year":"1957"},{"key":"S0007125000074511_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810310043008"},{"key":"S0007125000074511_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90002-U"},{"key":"S0007125000074511_ref56","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.4"},{"key":"S0007125000074511_ref146","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1176\/ajp.145.2.251","article-title":"Low frontal glucose utilization in chronic schizophrenia: a replication study","volume":"145","author":"Wolkin","year":"1988","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90162-X"},{"key":"S0007125000074511_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(90)90013-W"},{"key":"S0007125000074511_ref141","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(90)90006-R"},{"key":"S0007125000074511_ref57","doi-asserted-by":"crossref","unstructured":"Frith C. D. , Friston K. J. , Herold S. , et al (1995) Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task: evidence for a failure of inhibition in left superior temporal cortex. British Journal of Psychiatry, in press.","DOI":"10.1192\/bjp.167.3.343"},{"key":"S0007125000074511_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90121-F"},{"key":"S0007125000074511_ref27","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.156.2.216"},{"key":"S0007125000074511_ref30","volume-title":"Disordered Thought in Schizophrenia.","author":"Chapman","year":"1973"},{"key":"S0007125000074511_ref97","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290100001001"},{"key":"S0007125000074511_ref82","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(93)90045-K"},{"key":"S0007125000074511_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(93)90023-B"},{"key":"S0007125000074511_ref107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6849.327"},{"key":"S0007125000074511_ref112","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.158.1.8"},{"key":"S0007125000074511_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1989.tb03001.x"},{"key":"S0007125000074511_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/14.2.185"},{"key":"S0007125000074511_ref37","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810120087013"},{"key":"S0007125000074511_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800240070010"},{"key":"S0007125000074511_ref71","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/16.4.605"},{"key":"S0007125000074511_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90091-Y"},{"key":"S0007125000074511_ref131","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1176\/ajp.146.4.464","article-title":"Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study","volume":"146","author":"Suddath","year":"1989","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref3","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1980"},{"key":"S0007125000074511_ref40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1981.tb00765.x"},{"key":"S0007125000074511_ref77","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110061009"},{"key":"S0007125000074511_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810130037006"},{"key":"S0007125000074511_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790030028003"},{"key":"S0007125000074511_ref58","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.2"},{"key":"S0007125000074511_ref124","doi-asserted-by":"publisher","DOI":"10.1038\/368633a0"},{"key":"S0007125000074511_ref41","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820070025004"},{"key":"S0007125000074511_ref93","first-page":"168","article-title":"A PET $study of word generation in schizophrenia","volume":"11","author":"Liddle","year":"1994","journal-title":"Schizophrenia Research"},{"key":"S0007125000074511_ref60","volume-title":"Schizophrenia Genesis: the Origins of Madness.","author":"Gottesman","year":"1991"},{"key":"S0007125000074511_ref110","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.108.1.93"},{"key":"S0007125000074511_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90044-M"},{"key":"S0007125000074511_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800020042006"},{"key":"S0007125000074511_ref147","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120047007"},{"key":"S0007125000074511_ref78","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90890-4"},{"key":"S0007125000074511_ref91","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700032694"},{"key":"S0007125000074511_ref63","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800140021003"},{"key":"S0007125000074511_ref47","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.12.1290"},{"key":"S0007125000074511_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230045008"},{"key":"S0007125000074511_ref139","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1176\/ajp.144.2.151","article-title":"Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia","volume":"144","author":"Volkow","year":"1987","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref85","first-page":"1601","article-title":"A neurohistological correlate of schizophrenia","volume":"19","author":"Kovelman","year":"1984","journal-title":"Biological Psychiatry"},{"key":"S0007125000074511_ref61","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790100096013"},{"key":"S0007125000074511_ref104","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.151.6.744"},{"key":"S0007125000074511_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800010038005"},{"key":"S0007125000074511_ref75","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249090"},{"key":"S0007125000074511_ref14","first-page":"213","article-title":"Post-mortem structural analyses of schizophrenic brain: study designs and the interpretation of data","volume":"6","author":"Benes","year":"1988","journal-title":"Psychiatric Developments"},{"key":"S0007125000074511_ref53","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810150013003"},{"key":"S0007125000074511_ref135","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/18.2.159"},{"key":"S0007125000074511_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700017608"},{"key":"S0007125000074511_ref66","first-page":"115","volume-title":"Schizophrenia: Exploring the Spectrum of Psychosis","author":"Hall","year":"1994"},{"key":"S0007125000074511_ref69","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230032006"},{"key":"S0007125000074511_ref140","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.156.5.615"},{"key":"S0007125000074511_ref88","first-page":"73","volume-title":"Schizophrenia: the Major Issues","author":"Lantos","year":"1988"},{"key":"S0007125000074511_ref96","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.158.3.346"},{"key":"S0007125000074511_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91160-6"},{"key":"S0007125000074511_ref26","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790230045007"},{"key":"S0007125000074511_ref31","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110069010"},{"key":"S0007125000074511_ref80","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700029081"},{"key":"S0007125000074511_ref62","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790270015001"},{"key":"S0007125000074511_ref68","doi-asserted-by":"publisher","DOI":"10.1007\/BF01257080"},{"key":"S0007125000074511_ref52","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800190091013"},{"key":"S0007125000074511_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(90)90016-Y"},{"key":"S0007125000074511_ref115","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(94)90119-8"},{"key":"S0007125000074511_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.2.431"},{"key":"S0007125000074511_ref59","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800230088014"},{"key":"S0007125000074511_ref121","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890010203"},{"key":"S0007125000074511_ref42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1176\/ajp.142.1.78","article-title":"Clinical correlates of decreased anteroposterior gradients in positron emission tomography (PET) of schizophrenic patients","volume":"142","author":"DeLisi","year":"1985","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000074511_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120015004"},{"key":"S0007125000074511_ref13","first-page":"201","volume-title":"Schizophrenia: the Major Issues","author":"Bebbington","year":"1988"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000074511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T22:43:59Z","timestamp":1557787439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000074511\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":151,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["S0007125000074511"],"URL":"https:\/\/doi.org\/10.1192\/bjp.166.5.563","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}