{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:22Z","timestamp":1790710582312,"version":"4.1.0"},"reference-count":20,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":8282,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A large collaborative 8-week study has shown fluoxetine to be effective and safe in treating patients with bulimia nervosa. The present study evaluated fluoxetine over 16 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifteen US out-patient psychiatry clinics conducted a double-blind parallel study in men and women with DSM\u2013III\u2013R bulimia nervosa (483 patients entered, 398 randomised [3:1 ratio, fluoxetine 60 mg\/day or placebo], 225 completed). Outcome measures included change in vomiting and binge-eating episodes per week, Eating Disorder Inventory, Clinical Global Impressions and Patient's Global Impression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with placebo, fluoxetine treatment resulted in significantly greater reductions in vomiting (<jats:italic>F<\/jats:italic> [1,360] = 14.73, <jats:italic>P<\/jats:italic>&lt; 0.0001) and binge-eating (<jats:italic>F<\/jats:italic> [1,360] = 14.39, <jats:italic>P<\/jats:italic>=0.0002) episodes per week at endpoint and improvement in other outcome measures. Adverse event, vital sign and laboratory analyses indicated that fluoxetine was safe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fluoxetine appeared to be safe and effective in patients with bulimia nervosa for up to 16 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.166.5.660","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T01:31:20Z","timestamp":1224034280000},"page":"660-666","source":"Crossref","is-referenced-by-count":165,"title":["Long-Term Fluoxetine Treatment of Bulimia Nervosa"],"prefix":"10.1192","volume":"166","author":[{"given":"David J.","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki 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