{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:41:15Z","timestamp":1777110075350,"version":"3.51.4"},"reference-count":10,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":8221,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The detailed effects of mercury poisoning on cognitive function, brain anatomy and regional brain function are largely unknown. We report the case of a 38-year-old man who was exposed to toxic levels of inorganic mercury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Four years after exposure, the patient was assessed using magnetic resonance imaging (MRI), single-photon emission computerised tomography (SPECT) and detailed neuropsychological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient developed a myriad of physical and psychiatric complaints, including stomatitis, muscle spasm, tremor, skin rash and the psychiatric syndrome known as \u2018erythism\u2019 (Mad Hatter's disease). Neuropsychological evaluation revealed marked and significant deficits of attention concentration, particularly when under time pressure. The MRI scan was unremarkable; however, SPECT revealed hypermetabolism of the posterior cingulate cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mercury poisoning appeared to result in a dysregulation of posterior cingulate cortex, which was associated with attention\/concentration deficits and marked anxiety\/agitation.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.167.1.95","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:31:20Z","timestamp":1224048680000},"page":"95-98","source":"Crossref","is-referenced-by-count":51,"title":["The Neuropsychiatric Sequelae of Mercury Poisoning"],"prefix":"10.1192","volume":"167","author":[{"given":"R. E.","family":"O'Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Masterton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dougall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. P.","family":"Ebmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000063856_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0511(94)90046-9"},{"key":"S0007125000063856_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700025368"},{"key":"S0007125000063856_ref10","first-page":"435","article-title":"Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions","volume":"2","author":"Vogt","year":"1992","journal-title":"Cerebral Cortex"},{"key":"S0007125000063856_ref6","volume-title":"Organic Psychiatry. The Psychological Consequences of Cerebral Disorder","author":"Lishman","year":"1987"},{"key":"S0007125000063856_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90106-T"},{"key":"S0007125000063856_ref9","first-page":"105","article-title":"Effects of low exposure to inorganic mercury on psychological performance","volume":"47","author":"Soleo","year":"1990","journal-title":"British Journal of Industrial Medicine"},{"key":"S0007125000063856_ref4","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1993.1114"},{"key":"S0007125000063856_ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.181.4096.230"},{"key":"S0007125000063856_ref5","first-page":"370","article-title":"The outbreak of a neurological disorder in Minamata, Japan, and its relationship to the ingestion of seafood contaminated by mercuric compounds","volume":"1","author":"Kurland","year":"1960","journal-title":"World Neurology"},{"key":"S0007125000063856_ref7","first-page":"782","article-title":"Chronic neurobehavioural effects of elemental mercury in dentists","volume":"49","author":"Ngim","year":"1992","journal-title":"British Journal of Industrial Medicine"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000063856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T21:39:21Z","timestamp":1557783561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000063856\/type\/journal_article"}},"subtitle":["The Mad Hatter's Disease Revisited"],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["S0007125000063856"],"URL":"https:\/\/doi.org\/10.1192\/bjp.167.1.95","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}