{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:45:37Z","timestamp":1725623137466},"reference-count":10,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":8129,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The apolipoprotein E (ApoE) <jats:sub>\u220a<\/jats:sub>4 allele is associated with an increased risk of senile and probably presenile Alzheimer's disease. It is not yet clear whether the <jats:sub>\u220a<\/jats:sub>4 allele also influences the duration\/rate of progress of illness and the severity of the dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We have retrospectively examined a series of ApoE genotyped presenile and senile autopsy cases of Alzheimer's disease (AD) for length of illness and severity of pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We find no evidence that ApoE genotype affects the rate of progress of AD, but the degree of pathology at death may be increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It appears that the rate of progress of AD as a whole is independent of the ApoE genotype.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.167.4.533","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:31:20Z","timestamp":1224048680000},"page":"533-536","source":"Crossref","is-referenced-by-count":14,"title":["Apolipoprotein E Genotype and its Effect on Duration and Severity of Early and Late Onset Alzheimer's Disease"],"prefix":"10.1192","volume":"167","author":[{"given":"Jennie","family":"Norrman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David St","family":"Clair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000065715_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90867-2"},{"key":"S0007125000065715_ref3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"S0007125000065715_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92960-2"},{"key":"S0007125000065715_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-10b"},{"key":"S0007125000065715_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"S0007125000065715_ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9649"},{"key":"S0007125000065715_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1984.tb01995.x"},{"key":"S0007125000065715_ref2","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.1993.1023"},{"key":"S0007125000065715_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92823-K"},{"key":"S0007125000065715_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-74"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000065715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T20:50:52Z","timestamp":1557780652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000065715\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["S0007125000065715"],"URL":"https:\/\/doi.org\/10.1192\/bjp.167.4.533","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}