{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:44:42Z","timestamp":1784828682192,"version":"3.55.0"},"reference-count":16,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":7885,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We assessed associations of mood at 5\u20136 weeks postpartum with peripartum saliva cortisol and progesterone profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective study involved 120 primiparous women free of major marital, socioeconomic and health problems, who collected saliva twice daily from 2 weeks before delivery to day 35 postpartum. This allowed intensive characterisation of cortisol and progesterone profiles. At the conclusion of the study, mood was assessed according to standard criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven women developed major depression according to DSM\u2013III\u2013R criteria No associations emerged between progesterone and mood at 5 to 6 weeks. Lower levels of evening cortisol in the immediate peripartum period, were associated with postnatal depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study provides no support for the treatment strategy of progesterone augmentation following delivery, as a prophylactic against postnatal depression. The HPA axis and its associations with postnatal mood warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.168.6.739","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:35:17Z","timestamp":1224048917000},"page":"739-744","source":"Crossref","is-referenced-by-count":77,"title":["Cardiff Puerperal Mood and Hormone Study. III. Postnatal Depression at 5 to 6 Weeks Postpartum, and its Hormonal Correlates Across the Peripartum Period"],"prefix":"10.1192","volume":"168","author":[{"given":"Brian","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisetta","family":"Lovett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Read","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Newcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000144472_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(80)90038-0"},{"key":"S0007125000144472_ref1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1987"},{"key":"S0007125000144472_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1970.01750020068009"},{"key":"S0007125000144472_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6846.152"},{"key":"S0007125000144472_ref3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.2.191"},{"key":"S0007125000144472_ref5","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.6.782"},{"key":"S0007125000144472_ref6","unstructured":"Dalton K. (1989) Successful prophylactic progesterone for ideopathic post-natal depression. International Journal of Prenatal and Perinatal Studies, 322\u2013327."},{"key":"S0007125000144472_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6934.949"},{"key":"S0007125000144472_ref9","first-page":"141","article-title":"Non-genomic and genomic effects of steroids on neural activity","volume":"12","author":"McEwen","year":"1991","journal-title":"Trends in Neurosciences"},{"key":"S0007125000144472_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810330025004"},{"key":"S0007125000144472_ref12","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.136.4.339"},{"key":"S0007125000144472_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90034-H"},{"key":"S0007125000144472_ref16","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1093\/clinchem\/25.12.2030","article-title":"Radioimmunoassay of progesterone in saliva: application to the assessment of ovarian function","volume":"25","author":"Walker","year":"1979","journal-title":"Clinical Chemistry"},{"key":"S0007125000144472_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(86)90026-0"},{"key":"S0007125000144472_ref4","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.2.111"},{"key":"S0007125000144472_ref10","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000144472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:01:04Z","timestamp":1589000464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000144472\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["S0007125000144472"],"URL":"https:\/\/doi.org\/10.1192\/bjp.168.6.739","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6]]}}}