{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:05:17Z","timestamp":1789653917196,"version":"4.0.0"},"reference-count":38,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"unspecified","delay-in-days":7399,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We compared regional cerebral blood flow (rCBF) in three groups of patients with DSM\u2013III\u2013R anxiety disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifteen patients with obsessive\u2013compulsive disorder (OCD), 15 with panic disorder with agoraphobia (PA), and 16 with post-traumatic stress disorder (PTSD) and a similar group of healthy controls were assessed on brain-dedicated high-resolution SPET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MANOVA revealed significant rCBF differences between diagnostic groups (<jats:italic>F<\/jats:italic>=4.4; d.f.=3, 57; <jats:italic>P<\/jats:italic>=0.007) and between cerebral regions (<jats:italic>F<\/jats:italic>=6.4; d.f.=1, 57; <jats:italic>P<\/jats:italic>=0.01) in OCD and PTSD compared with PA and healthy controls, limited to bilateral superior frontal cortices and right caudate nuclei. Whole brain blood flow correlated positively with anxiety (<jats:italic>r<\/jats:italic>=0.24, <jats:italic>n<\/jats:italic>=46, P=0.05). Beck depression scores correlated significantly negatively with left caudate rCBF (<jats:italic>r<\/jats:italic>= \u20130.24, <jats:italic>n<\/jats:italic>=46, <jats:italic>P<\/jats:italic>=0.05) and right caudate rCBF (<jats:italic>r<\/jats:italic>= \u20130.31, <jats:italic>n<\/jats:italic>=46, <jats:italic>P<\/jats:italic>=0.02). PTSD syndrome severity correlated significantly negatively with the left caudate (<jats:italic>r<\/jats:italic>=-0.49, <jats:italic>n<\/jats:italic>=16. <jats:italic>P<\/jats:italic>=0.03) and with right caudate rCBF (<jats:italic>r<\/jats:italic>=-0.7, <jats:italic>n<\/jats:italic>=16, <jats:italic>P<\/jats:italic>=0.001)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Functional rCBF differences in anxiety disorders could relate to repetitive, intrusive, distressing mental activity, prominent in both OCD and PTSD.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.171.4.346","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:36:56Z","timestamp":1224049016000},"page":"346-350","source":"Crossref","is-referenced-by-count":106,"title":["Brain blood flow in anxiety disorders"],"prefix":"10.1192","volume":"171","author":[{"given":"J. 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