{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:39:37Z","timestamp":1775065177716,"version":"3.50.1"},"reference-count":7,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"unspecified","delay-in-days":7307,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A 17-year-old boy suffering from a severe schizophrenic disorder of the paranoid type and mental retardation did not respond to treatment with typical antipsychotics, whereas under clozapine treatment he showed a favourable response. Discontinuation of clozapine led to an acute psychotic relapse. During clozapine treatment the patient developed severe neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method and Results<\/jats:title><jats:p>Due to the history of unsatisfactory response to traditional antipsychotics, clozapine treatment was continued despite white blood cell (WBC) decline. Concomitant treatment with G-CSF was followed by a rapid normalisation of WBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case report is not intended to challenge the clinical practice of discontinuing clozapine upon the development of neutropenia\/agranulocytosis, but rather to stimulate further research in the pathophysiology and clinical consequences of a clozapine rechallenge after a WBC decline, especially in patients with a rather complex symptomatology where no sufficient therapeutic results can be achieved with any other pharmacological intervention than clozapine.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.172.1.82","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:40:02Z","timestamp":1224049202000},"page":"82-84","source":"Crossref","is-referenced-by-count":54,"title":["Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor (G-CSF)"],"prefix":"10.1192","volume":"172","author":[{"given":"B.","family":"Sperner-Unterweger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Czeipek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gaggl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Geissler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Spiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. W.","family":"Fleischhacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"S0007125000149220_ref4","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/0140-6736(93)92980-8","article-title":"G-CSF levels during spontaneous recovery from drug-induced agranulocytosis","volume":"342","author":"Fulcata","year":"1993","journal-title":"Lancet"},{"key":"S0007125000149220_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290303"},{"key":"S0007125000149220_ref3","first-page":"111","article-title":"The treatment of clozapine-associated agranulocytosis with granulocyte colony-stimulating factor (G-CSF)","volume":"32","author":"Chengappa","year":"1996","journal-title":"Psychopharmacology Bulletin"},{"key":"S0007125000149220_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93116-5"},{"key":"S0007125000149220_ref6","first-page":"287","article-title":"Transient \u2018benign\u2019 neutropenia induced by clozapine","volume":"28","author":"Hummer","year":"1992","journal-title":"Psychopharmocology Bulletin"},{"key":"S0007125000149220_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91625-I"},{"key":"S0007125000149220_ref2","first-page":"245","article-title":"Granulocyte-macrophage colony stimulation factor (GM-CSF) treatment of clozapine-induced agranulocytosis: a case report","volume":"53","author":"Barnas","year":"1992","journal-title":"Journal of Clinical Psychiatry"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000149220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T19:32:30Z","timestamp":1557603150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000149220\/type\/journal_article"}},"subtitle":["Remission despite continuous treatment with clozapine"],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["S0007125000149220"],"URL":"https:\/\/doi.org\/10.1192\/bjp.172.1.82","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}