{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:19:52Z","timestamp":1761862792086},"reference-count":32,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"unspecified","delay-in-days":7217,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Increased central serotonin (5-HT) function has been hypothesised to be a vulnerability trait in anorexia nervosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen women with a history of DSM\u2013III\u2013R anorexia nervosa and 18 female controls were examined. The subjects had recovered weight and menstrual function. A placebo-controlled d-fenfluramine test was used. Subjects ingested d-fenfluramine or placebo and after three hours were offered a \u2018free\u2019 meal. The amounts eaten were recorded and plasma Cortisol and prolactin levels were measured. Questionnaires related to eating attitudes and behaviour, to personality, and to mood were administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unlike the control subjects, those recovered from anorexia nervosa did not show the expected appetite-suppressing responses to d-fenfluramine; their eating attitudes and behaviour were more restrained, \u2018negative\u2019 perfectionism was more pronounced, and post-meal plasma Cortisol levels did not rise as expected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results do not suggest that increased central 5-HT function is a trait marker in anorexia nervosa, but dysregulation in part of the central 5-HT system may be a vulnerability factor. The flattened post-meal response to Cortisol in the subjects who had recovered from anorexia nervosa suggests that their hypothalamic\u2013pituitary\u2013adrenal axis may be altered and deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.172.4.351","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T05:40:02Z","timestamp":1224049202000},"page":"351-358","source":"Crossref","is-referenced-by-count":52,"title":["Neuroendocrine, appetitive and behavioural responses to d-fenfluramine in women recovered from anorexia nervosa"],"prefix":"10.1192","volume":"172","author":[{"given":"Anne","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stafford","family":"Lightman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain C.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Treasure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"S0007125000149943_ref32","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.163.2.195"},{"key":"S0007125000149943_ref31","first-page":"347","volume-title":"Handbook of Assessment Methods for Bating Behaviors and Weight-Related Problems","author":"Williamson","year":"1995"},{"key":"S0007125000149943_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291797004881"},{"key":"S0007125000149943_ref28","first-page":"65","volume-title":"Handbook of Eating Disorders: Theory, Treatment, and Research","author":"Treasure","year":"1995"},{"key":"S0007125000149943_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(94)00192-U"},{"key":"S0007125000149943_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90468-7"},{"key":"S0007125000149943_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(96)00098-8"},{"key":"S0007125000149943_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(94)90001-9"},{"key":"S0007125000149943_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810300068010"},{"key":"S0007125000149943_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90113-8"},{"key":"S0007125000149943_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790150040007"},{"key":"S0007125000149943_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830180043005"},{"key":"S0007125000149943_ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-2-319"},{"key":"S0007125000149943_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180093014"},{"key":"S0007125000149943_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199309)14:2<213::AID-EAT2260140211>3.0.CO;2-P"},{"key":"S0007125000149943_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(95)00026-J"},{"key":"S0007125000149943_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(93)90006-P"},{"key":"S0007125000149943_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(90)90270-A"},{"key":"S0007125000149943_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1991.tb03768.x"},{"key":"S0007125000149943_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(95)00001-5"},{"key":"S0007125000149943_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(93)90108-S"},{"key":"S0007125000149943_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(87)90040-0"},{"key":"S0007125000149943_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700026775"},{"key":"S0007125000149943_ref8","first-page":"317","volume-title":"Binge Eating: Nature. 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