{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:12:06Z","timestamp":1784124726552,"version":"3.55.0"},"reference-count":42,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":6882,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In the treatment of panic disorder with agoraphobia, the efficacy of pharmacological, psychological and combined treatments has been established. Unanswered questions concern the relative efficacy of such treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To demonstrate that moclobemide and cognitive\u2013behavioural therapy (CBT) are effective singly and more effective in combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty-five patients were randomly assigned to an eight-week treatment of: moclobemide plus CBT; moclobemide plus clinical management (\u2018psychological placebo\u2019); placebo plus CBT; or placebo plus clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparisons between treatments revealed strong effects for CBT. Moclobemide with clinical management was not superior to placebo. The combination of moclobemide with CBT did not yield significantly better short-term results than CBT with placebo. The CBT results remained stable during a six-month follow-up, although a substantial proportion of patients treated with placebo plus CBT needed additional treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CBT was highly effective in the treatment of panic disorder with agoraphobia and reduced agoraphobia to levels that were comparable to those of non-clinical controls.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.174.3.205","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T01:41:36Z","timestamp":1224034896000},"page":"205-212","source":"Crossref","is-referenced-by-count":57,"title":["Randomised placebo-controlled trial of moclobemide, cognitive\u2013behavioural therapy and their combination in panic disorder with agoraphobia"],"prefix":"10.1192","volume":"174","author":[{"given":"Bernd","family":"Loerch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechthild","family":"Graf-Morgenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hautzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Sandmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Benkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000261898_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(79)90041-X"},{"key":"S0007125000261898_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(93)90027-Y"},{"key":"S0007125000261898_ref41","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780140065007"},{"key":"S0007125000261898_ref39","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.3.353"},{"key":"S0007125000261898_ref38","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700029986"},{"key":"S0007125000261898_ref37","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199708000-00006"},{"key":"S0007125000261898_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7894(05)80149-2"},{"key":"S0007125000261898_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1995.tb05923.x"},{"key":"S0007125000261898_ref27","first-page":"12-1","volume-title":"Manual for the EDCEU Assessment Battery 2","author":"Guy","year":"1976"},{"key":"S0007125000261898_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(95)00048-8"},{"key":"S0007125000261898_ref12","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.165.3.315"},{"key":"S0007125000261898_ref31","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780140053006"},{"key":"S0007125000261898_ref7","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.61.2.317"},{"key":"S0007125000261898_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.6.759"},{"key":"S0007125000261898_ref30","volume-title":"The Anxiety Disease","author":"Sheehan","year":"1986"},{"key":"S0007125000261898_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90140-8"},{"key":"S0007125000261898_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820130046008"},{"key":"S0007125000261898_ref2","first-page":"32","article-title":"Cognitive\u2013behavioral therapy for panic disorder: current status","volume":"58","author":"Barlow","year":"1997","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000261898_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110013002"},{"key":"S0007125000261898_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7916(92)90034-G"},{"key":"S0007125000261898_ref1","first-page":"59","volume-title":"Treatment of Panic Disorder. 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