{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:56:20Z","timestamp":1791287780193,"version":"4.3.0"},"reference-count":26,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":6516,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Most prior studies of panic-depression comorbidity have been limited methodologically by use of small clinical samples and incomplete analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>General population data were used to study the association of lifetime and recent (12 months) panic\u2013depression comorbidity with symptom severity, impairment, course and help-seeking in the National Comorbidity Survey (NCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The NCS is a nationally representative survey of the prevalences and correlates of major DSM\u2013III\u2013R disorders in the US household population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Strong lifetime and current comorbidity were found between panic and depression. Comorbidity was associated with greater symptom severity, persistence, role impairment, suicidality and help-seeking, with many findings persisting after controlling for additional comorbid diagnoses. Findings did not differ according to which disorder was chronologically primary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both lifetime and current panic\u2013depression comorbidity are markers for more severe, persistent and disabling illness. Neither additional comorbid diagnoses nor the primary\u2013secondary distinction were important moderators of these associations.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.176.3.229","type":"journal-article","created":{"date-parts":[[2002,8,29]],"date-time":"2002-08-29T21:36:18Z","timestamp":1030656978000},"page":"229-235","source":"Crossref","is-referenced-by-count":302,"title":["Lifetime panic\u2013depression comorbidity in the National Comorbidity Survey"],"prefix":"10.1192","volume":"176","author":[{"given":"Peter 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