{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:04:15Z","timestamp":1792184655309,"version":"4.4.0"},"reference-count":26,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":6029,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>No controlled trial of treatment of generalised social phobia has been conducted in general practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the efficacy of sertraline or exposure therapy, administered alone or in combination in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Study was of a randomised, double-blind design. Patients (<jats:italic>n<\/jats:italic>=387) received sertraline 50\u2013150 mg or placebo for 24 weeks. Patients were additionally randomised to exposure therapy or general medical care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sertraline-treated patients were significantly more improved than non-sertraline-treated patients (\u03c7<jats:sup>2<\/jats:sup>=12.53,<jats:italic>P<\/jats:italic>&lt;0.001; odds ratio=0.534; 95% CI 0.347\u20130.835). No significant difference was observed between exposure\u2014 and non-exposure-treated patients (\u03c7<jats:sup>2<\/jats:sup>=2.18,<jats:italic>P<\/jats:italic>=0.140; odds ratio=0.732; 95% CI 0.475\u20131.134). In the pairwise comparisons, combined sertraline and exposure (\u03c7<jats:sup>2<\/jats:sup>=12.32;<jats:italic>P<\/jats:italic>&lt;0.001) and sertraline (\u03c7<jats:sup>2<\/jats:sup>=10.13;<jats:italic>P<\/jats:italic>=0.002) were significantly superior to placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sertraline is an effective treatment for generalised social phobia. Combined treatment with sertraline and exposure therapy, conducted by the general practitioner, may enhance the treatment efficacy in primary care.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.179.1.23","type":"journal-article","created":{"date-parts":[[2002,8,29]],"date-time":"2002-08-29T21:36:18Z","timestamp":1030656978000},"page":"23-30","source":"Crossref","is-referenced-by-count":175,"title":["Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalised social phobia"],"prefix":"10.1192","volume":"179","author":[{"given":"S.","family":"Blomhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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