{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:47:32Z","timestamp":1784753252360,"version":"3.55.0"},"reference-count":36,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":5967,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Strong links exist between juvenile and adult depression but comorbid conduct disorder in childhood may mitigate this continuity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To test the impact of comorbid conduct disorder on psychiatric adult outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A group of 149 subjects assessed at the Maudsley Hospital in the period 1970\u20131983 and meeting DSM\u2013IV criteria for major depressive disorder with (<jats:italic>n<\/jats:italic>=53) or without (<jats:italic>n<\/jats:italic>=96) conduct disorder were interviewed 20 years later. Data were collected on the lifetime history of psychiatric disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adult depressive recurrence was high for major depression (62.4%) and any depression (75.2%), and survival analyses showed no difference between the two groups. The group with conduct disorders had higher rates of drug misuse and dependence, alcoholism and antisocial personality disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescent depression carries an elevated risk of adult depression irrespective of comorbidity. 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